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Titolo:
Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome
Autore:
Miyamoto, A; Oki, J; Takahashi, S; Okuno, A;
Indirizzi:
Asahikawa Med Coll, Dept Pediat, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
BRAIN & DEVELOPMENT
fascicolo: 1, volume: 21, anno: 1999,
pagine: 59 - 62
SICI:
0387-7604(199901)21:1<59:SMKALM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATTERNS; CHILDREN;
Keywords:
melatonin; Rett syndrome; sleep disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Miyamoto, A Asahikawa0788510,l, Dept Pediat, 4-5-3-11 Nishikagura, Asahikawa, Hokkaido Asahikawa Med Coll 4-5-3-11 Nishikagura Asahikawa Hokkaido Japan 0788510
Citazione:
A. Miyamoto et al., "Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome", BRAIN DEVEL, 21(1), 1999, pp. 59-62

Abstract

We studied the circadian rhythm of serum melatonin levels in two patients with classical Rett syndrome having severe sleep disorders; serum melatoninlevels were measured before and during melatonin treatment using radioimmnoassay. Patient 1 had a free-running rhythm of sleep-wake cycle from 3 years of age. At the age of 3 years, the peak time of melatonin was delayed 6 hcompared to normal control and the peal; value was at the lower limit. Patient 2 had a fragmented sleep pattern accompanied by night screaming from 1year and 6 months of age. At the age of 10 years, the peak time of melatonin secretion was normal but the peak value was at the lower limit. These patients were given 5 mg melatonin orally prior to bedtime. Exogenous melatonin dramatically improved the sleep-wake cycle in patient 1. In patient 2, exogenous melatonin showed a hypnotic effect but early morning awakenings occurred occasionally. When melatonin treatment was stopped, the sleep disorders recurred and re-administration of 3 mg melatonin was effective in both patients. The effect was maintained over 2 years without any adverse effects. These findings suggests that sleep disorders in patients with Rett syndrome may relate with an impaired secretion of melatonin. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:25:22