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Titolo:
Apoptosis in neurodegenerative diseases: the role of mitochondria
Autore:
Tatton, WG; Olanow, CW;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 eurol, New York, NY 10029 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
fascicolo: 2, volume: 1410, anno: 1999,
pagine: 195 - 213
SICI:
0005-2728(19990209)1410:2<195:AINDTR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY TRANSITION PORE; PROGRAMMED CELL-DEATH; AMYOTROPHIC-LATERAL-SCLEROSIS; CEREBELLAR GRANULE NEURONS; DNA STRAND BREAKS; CYTOCHROME-OXIDASE ACTIVITY; ISCHEMIC BRAIN INJURY; AMYLOID-BETA PROTEIN; COMPLEX-I DEFICIENCY; NERVE GROWTH-FACTOR;
Keywords:
apoptosis; mitochondrion; neurodegenerative disease; permeability transition pore;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
198
Recensione:
Indirizzi per estratti:
Indirizzo: Olanow, CW CUNYYork,inai Sch Med, Dept Neurol, 1 Gustave Levy Pl,Annenberg14-94, New CUNY Mt Sinai Sch Med 1 Gustave Levy Pl,Annenberg 14-94 New York NY USA 10029
Citazione:
W.G. Tatton e C.W. Olanow, "Apoptosis in neurodegenerative diseases: the role of mitochondria", BBA-BIOENER, 1410(2), 1999, pp. 195-213

Abstract

Nerve cell death is the central feature of the human neurodegenerative diseases. It has long been thought that nerve cell death in these disorders occurs by way of necrosis, a process characterized by massive transmembrane ion currents, compromise of mitochondrial ATP production, and the formation of high levels of reactive oxygen species combining to induce rapid disruption of organelles, cell swelling, and plasma membrane rupture with a secondary inflammatory response. Nuclear DNA is relatively preserved. Recent evidence now indicates that the process of apoptosis rather than necrosis primarily contributes to nerve cell death in neurodegeneration. This has opened up new avenues for understanding the pathogenesis of neurodegeneration and may lead to new and more effective therapeutic approaches to these diseases. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:36:39