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Titolo:
Relationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults - The cardiovascular health study
Autore:
Manolio, TA; Burke, GL; OLeary, DH; Evans, G; Beauchamp, N; Knepper, L; Ward, B;
Indirizzi:
NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27109 USAWake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Tufts Univ, New England Med Ctr, Dept Radiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Med Ctr, Dept Radiol, Boston, MA 02111 USA Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA Univ, Dept Radiol, Baltimore, MD USA Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Neurol, Pittsburgh, PA 15260 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 2, volume: 19, anno: 1999,
pagine: 356 - 365
SICI:
1079-5642(199902)19:2<356:ROCMFT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER LESIONS; TRANSIENT ISCHEMIC ATTACK; BRAIN ATROPHY; RISK-FACTORS; BLOOD-FLOW; PLAQUE; DISEASE; ABNORMALITIES; HEMORRHAGE; INFARCTION;
Keywords:
stroke; cerebrovascular disorders; carotid arteries; atherosclerosis; aged; epidemiology; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Manolio, TA NHLBI,,Div Epidemiol & Clin Applicat, 6701 Rockledge Dr,Room 8160, Bethesda NHLBI 6701 Rockledge Dr,Room 8160 Bethesda MD USA 20892 thesda
Citazione:
T.A. Manolio et al., "Relationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults - The cardiovascular health study", ART THROM V, 19(2), 1999, pp. 356-365

Abstract

Cerebral magnetic resonance imaging (MRI) has demonstrated a high prevalence of infarct-like lesions, white matter hyperintensities, and evidence of cerebral atrophy in older adults. While these findings are generally believed to be related to ischemia and atherosclerosis, their relationship to atherosclerosis in the carotid arteries remains to be explored. Study subjectswere part of the multicenter Cardiovascular Health Study, a cross-sectional study of 3502 women and men greater than or equal to 65 years of age undergoing cranial MRI and carotid ultrasonography. MRI infarcts were detected in 1068 participants (29.3%) and measurable carotid plaque in 2745 (75.3%). MRI infarcts, ventricular and sulcal widening, and white matter score werestrongly associated with carotid intimal-medial thickness (IMT) and stenosis degree after adjustment for age and sex (all P < 0.01). Associations with plaque characteristics were less strong and less consistent; MRI infarctswere weakly associated only with surface irregularity, and ventricular size was weakly associated only with lesion density (both P < 0.04). In contrast, sulcal widening was strongly related to plaque characteristics, with scores being higher in those with heterogeneous and irregular plaque (both P < 0.009). Adjustment for other risk factors, and for carotid IMT/stenosis, removed associations of MRI findings with plaque characteristics except forweak relationships remaining between MRI infarcts and surface irregularityand between sulcal score and heterogeneous plaque (both P < 0.03). MRI abnormalities show strong and consistent relationships with increasing carotidIMT and stenosis degree but less strong associations with plaque characteristics, especially after adjusting for IMT and stenosis.

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Documento generato il 25/11/20 alle ore 15:43:53