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Titolo:
Identification and quantification by LC-MS and LC-ICP MS of arsenic species in urine of rats chronically exposed to dimethylarsinic acid (DMAA)
Autore:
Inoue, Y; Date, Y; Sakai, T; Shimizu, N; Yoshida, K; Chen, H; Kuroda, K; Endo, G;
Indirizzi:
Yokogawa Analyt Syst Inc, R&D Div, Musashino, Tokyo 180, Japan Yokogawa Analyt Syst Inc Musashino Tokyo Japan 180 hino, Tokyo 180, Japan Osaka City Univ, Sch Med, Dept Prevent Med & Environm Hlth, Abeno Ku, Osaka Osaka City Univ Osaka Japan 545 ent Med & Environm Hlth, Abeno Ku, Osaka
Titolo Testata:
APPLIED ORGANOMETALLIC CHEMISTRY
fascicolo: 2, volume: 13, anno: 1999,
pagine: 81 - 88
SICI:
0268-2605(199902)13:2<81:IAQBLA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION CHROMATOGRAPHY; MASS-SPECTROMETRY; MICE; METABOLISM; EXCRETION; HAMSTER; BIOTRANSFORMATION; SPECIATION; RABBITS;
Keywords:
identification; quantification; organoarsenic species; rat urine; liquid chromatography mass spectrometry; electrospray ionization; inductively coupled mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, Y Yokogawa Analyt Syst Inc, R&D Div, 11-19 Naka Cho 2 Chome, Musashino, Tokyo Yokogawa Analyt Syst Inc 11-19 Naka Cho 2 Chome Musashino Tokyo Japan 180
Citazione:
Y. Inoue et al., "Identification and quantification by LC-MS and LC-ICP MS of arsenic species in urine of rats chronically exposed to dimethylarsinic acid (DMAA)", APPL ORGAN, 13(2), 1999, pp. 81-88

Abstract

The potential of liquid chromatography-mass spectrometry (LC-MS) using electrospray ionization (ESI) was investigated for the identification and quantification of organoarsenic species excreted in rats urine chronically exposed to dimethylarsinic acid (DMAA). Quantification was performed by both LC-ESI-MS and LC-inductively coupled plasma mass spectrometry (ICP-MS), The detection limits of organoarsenic species in LC-ESI-MS with cation-exchange chromatography were 75-200 pg as arsenic. Although there are about ten times higher than that of LC-ICP-MS, LC-ESI-MS had a low enough detection limitto determine major metabolic arsenic species in the urine. LC-ESI-MS was applied to the identification of organoarsenic species in the urine. Major arsenic peaks in urine were identified as DMAA and trimethylarsine oxide using agreement of the spectra and retention times. Three unidentified arsenicpeaks were found in the urine; one of these was determined to be tetramethylarsonium ion by agreement of both the spectrum and the retention time. LC-ESI-MS and LC-ICP-MS were also used to quantify organoarsenic: in urine: good agreement between LC-ESI-MS and LC-ICP-MS was obtained. Copyright (C) 1999 John Wiley & Sons, Ltd.

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Documento generato il 15/07/20 alle ore 20:03:32