Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interleukin-6 synthesis and IgE overproduction in children with perinatal human immunodeficiency virus-type 1 infection
Autore:
de Martino, M; Rossi, ME; Azzari, C; Chiarelli, F; Galli, L; Vierucci, A;
Indirizzi:
Univ Chieti, Dept Med, Sect Pediat, I-66100 Chieti, Italy Univ Chieti Chieti Italy I-66100 Med, Sect Pediat, I-66100 Chieti, Italy Univ Florence, Dept Pediat, Florence, Italy Univ Florence Florence Italy niv Florence, Dept Pediat, Florence, Italy
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 2, volume: 82, anno: 1999,
pagine: 212 - 216
SICI:
1081-1206(199902)82:2<212:ISAIOI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; HIV-INFECTION; DISEASE PROGRESSION; CYTOKINE PRODUCTION; LYMPHOCYTES; SERUM; INDIVIDUALS; EXPRESSION; INFANTS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: de Martino, M Univ Chieti, Dept Med, Sect Pediat, Via Vestini, I-66100 Chieti, Italy Univ Chieti Via Vestini Chieti Italy I-66100 Chieti, Italy
Citazione:
M. de Martino et al., "Interleukin-6 synthesis and IgE overproduction in children with perinatal human immunodeficiency virus-type 1 infection", ANN ALLER A, 82(2), 1999, pp. 212-216

Abstract

Background: Unbalanced interleukin network and elevated IL-6 synthesis an suggested mechanisms of immunoglobulin overproduction in children with perinatal human immunodeficiency virus-type 1 (HIV-1) infection. Objective: To investigate whether elevated IL-6 synthesis is a general mechanism of immunoglobulin overproduction in perinatal HIV-1 infection. Methods: In vitro spontaneous and phytohaemoagglutinin (PHA)-stimulated IL-6 and IL-2 synthesis, serum IgE, IgG, IgA, and IgM levels, CD4(+) T-lymphocyte counts, and HIV-1 RNA copy numbers were cross-sectionally determined in 31 children with perinatal HIV-1 infection. Children with immunoglobulin z-scores in the highest quartile were defined as children with high immunoglobulin level. Relationships between interleukin synthesis, high immunoglobulin levels, and HIV-1 related disease were studied. Results: Children with high IEE levels had higher spontaneous IL-6 synthesis (1337 +/- 138 pg/mL) compared with those without high IgE levels (861 +/- 194 pg/mL; P < .001). By contrast, spontaneous IL-6 synthesis was similarin children with or without high IgG, IgA, or IgM levels. Decreased PHA-stimulated IL-2 synthesis, low CD4(+) lymphocyte counts, elevated HIV-1 RNA copy numbers, and severe disease correlated with high IEE (but not IgG, IgA,and IgM) levels. IgG, IgA, and ISM levels correlated with each other, but not with IgE levels. Conclusion: The increased IL-6 synthesis in HIV-1(+) children may affect IgE rather than other immunoglobulin isotype levels. Overall results suggestthat IgE and IgG, IgA, IgM overproduction have distinct underlying mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:26:49