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Titolo:
Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals
Autore:
Elbers, JMH; Asscheman, H; Seidell, JC; Gooren, LJG;
Indirizzi:
Free&Univ Amsterdam Hosp, Div Endocrinol Androl, Res Inst Endocrinol MetabFree Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB docrinol Metab Natl,Inst Publ Hlth & Environm Protect, Dept Chron Dis & Environm Epidemiol Natl Inst Publ Hlth & Environm Protect Bilthoven Netherlands NL-3720 BA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 39, anno: 1999,
pagine: E317 - E325
SICI:
0193-1849(199902)39:2<E317:EOSSHO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADIPOSE-TISSUE DISTRIBUTION; EARLY POSTMENOPAUSAL WOMEN; GROWTH-FACTOR-I; BODY-FAT; REPLACEMENT THERAPY; VISCERAL FAT; TESTOSTERONE TREATMENT; MUSCLE SIZE; OBESE MEN; FREE MASS;
Keywords:
estrogens; androgens; sex differences; regional fat distribution; thigh muscle mass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Elbers, JMH Free&Univ Amsterdam Hosp, Div Endocrinol Androl, Res Inst Endocrinol Metab Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB ab
Citazione:
J.M.H. Elbers et al., "Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals", AM J P-ENDO, 39(2), 1999, pp. E317-E325

Abstract

We investigated prospectively the effect of sex steroids on regional fat depots and thigh muscle mass in adult transsexuals. Ethinyl estradiol in combination with cyproterone acetate, a progestational antiandrogen, was givento 20 male-to-female (M-F) transsexuals, and parenteral testosterone esters were given to 17 female-to-male (F-M) transsexuals. Before and after 12 mo of cross-sex hormone administration, several anthropometric measurements (weight, skinfolds, body circumferences, and bioimpedance) were performed, and transverse magnetic resonance images were obtained at the level of the abdomen, hip, and thigh to quantify fat depots (subcutaneous and visceral) and muscle areas. We observed that treatment with ethinyl estradiol in M-F transsexuals induced a significant increase in all subcutaneous fat depots,with a lesser but proportional and significant increase in the visceral fat depot and a decrease in thigh muscle area. Testosterone administration inF-M transsexuals markedly increased thigh muscle area, reduced subcutaneous fat deposition at all levels measured, but slightly increased the visceral fat area. We conclude that sex steroid hormones are important determinants of the sex-specific localization of body fat.

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Documento generato il 03/12/20 alle ore 15:50:25