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Titolo:
Maternal and neonatal infection rates with three different protocols for prevention of group B streptococcal disease
Autore:
Locksmith, GJ; Clark, P; Duff, P;
Indirizzi:
Univesville,, Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Gain Univ Florida Gainesville FL USA 32610 necol, Div Maternal Fetal Med, Gain
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 2, volume: 180, anno: 1999,
parte:, 1
pagine: 416 - 422
SICI:
0002-9378(199902)180:2<416:MANIRW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRETERM PREMATURE RUPTURE; DOUBLE-BLIND TRIAL; ANTIBIOTIC-THERAPY; MEMBRANES; PROPHYLAXIS; AMPICILLIN; PENICILLIN; MORBIDITY;
Keywords:
chorioamnionitis; endometritis; group B streptococcal infection; prevention strategy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Locksmith, GJ Univesville,, Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Gain Univ Florida Gainesville FL USA 32610 ernal Fetal Med, Gain
Citazione:
G.J. Locksmith et al., "Maternal and neonatal infection rates with three different protocols for prevention of group B streptococcal disease", AM J OBST G, 180(2), 1999, pp. 416-422

Abstract

OBJECTIVES: We compared maternal and neonatal infection rates under 3 different group B streptococcal prevention strategies and also evaluated reasons for each protocol's failures in preventing neonatal disease. STUDY DESIGN: Women who were delivered at our center from August 1, 1991, through April 30, 1998, were managed by 1 of 3 protocols for prevention of early-onset neonatal group B streptococcal infection: a selective screeningprotocol, The American College of Obstetricians and Gynecologists protocol, and the Centers for Disease Control and Prevention-recommended universal screening strategy. We compared maternal infection rates and neonatal groupB streptococcal infection rates under each protocol. We also compared reasons for each protocol's failures in preventing neonatal infection. RESULTS: Clinical chorioamnionitis rates were 7.4% with selective screening, 7.7% under The American College of Obstetricians and Gynecologists' protocol, and 5.2% with universal screening (relative risk 0.7, 95% confidence interval 0.6-0.8). Endometritis rates were 4.0% with selective screening, 4.6% with The American College of Obstetricians and Gynecologists protocol, and 2.8% with universal screening (relative risk 0.7, 95% confidence interval 0.6-0.8). Overall neonatal group B streptococcal infection rates were lower under the 2 more recent strategies, but not significantly so. Despite the ability of universal screening to find more women at risk for group B streptococcal transmission, half of the neonatal infections under this protocol occurred when the mothers were not considered candidates for prophylaxis. CONCLUSIONS: The Centers for Disease Control and Prevention-endorsed universal screening strategy for group B streptococcal infection prevention was associated with significantly lower rates of clinical chorioamnionitis and endometritis than were the other strategies. We were unable to document statistically significant improvement in neonatal outcome under the universal screening protocol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:23:03