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Titolo:
Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin-binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex
Autore:
Brieske, N; Schenker, M; Schnibbe, T; Quentin-Millet, MJ; Achtman, M;
Indirizzi:
Max Planck Inst Mol Genet, D-14195 Berlin, Germany Max Planck Inst Mol Genet Berlin Germany D-14195 D-14195 Berlin, Germany Pasteur Merieux Connaught, F-69280 Marcy Letoile, France Pasteur Merieux Connaught Marcy Letoile France F-69280 y Letoile, France
Titolo Testata:
VACCINE
fascicolo: 7-8, volume: 17, anno: 1999,
pagine: 731 - 744
SICI:
0264-410X(19990226)17:7-8<731:HARTAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMORAL IMMUNE-RESPONSE; OUTER-MEMBRANE PROTEIN; SEROGROUP-A; MENINGOCOCCAL DISEASE; BACTERICIDAL ANTIBODIES; CONJUGATE VACCINE; WEST-AFRICA; EPIDEMIC; STRAINS; FEATURES;
Keywords:
meningococci; immunogenicity; nasopharyngeal carriage; invasive disease; vaccine development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Achtman, M Max Planck Inst Mol Genet, Ihnestr 73, D-14195 Berlin, Germany Max Planck Inst Mol Genet Ihnestr 73 Berlin Germany D-14195 ny
Citazione:
N. Brieske et al., "Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin-binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex", VACCINE, 17(7-8), 1999, pp. 731-744

Abstract

The protein sequences of the IgA1 protease, TbpA and TbpB proteins differ between meningococci representative of serogroup A, subgroup IV-1 from epidemic disease in The Gambia and serogroup C, ET-37 complex from endemic disease in Mali. The uniformity of restriction endonuclease sites was determined for the iga, tbpA and tbpB genes among strains of both clonal lineages. Rare isolates had acquired a variant tbpAB operon by horizontal genetic exchange but all other strains were uniform within each clonal lineage. The quantitative levels of IgG to capsular polysaccharide, IgA1 protease and TBP complex were measured in paired acute phase and convalescent phase sera fromThe Gambia and from Mali using antigens from the homologous clonal lineages. IgG levels to these antigens were also measured in paired sera from healthy Gambians who permanently carried meningococci in the nasopharynx or didnot. The results showed that disease stimulated IgG to each antigen in Mall and to all but TBP complex in The Gambia. Similarly, higher levels of IgGwere found in sera from permanent carriers than in sera from permanent non-carriers. Acute phase sera from Mall contained low levels of IgG to C capsular polysaccharide (geometric mean value of 0.3 mu g ml(-1)) while such sera from The Gambia contained higher and potentially protective levels of IgG to A polysaccharide (geometric mean of 5.5 mu g ml(-1)). The concentrations of IgG to TBP complex in acute phase sera were higher and IgG to IgA1 protease was even higher, suggesting that intermediate levels of IgG to theseproteins do not protect against disease. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:26:48