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Titolo:
Identification of murine cytotoxic T-lymphocyte epitopes of bovine herpesvirus 1
Autore:
Zatechka, DS; Hegde, NR; Hariharan, K; Srikumaran, S;
Indirizzi:
Univ Nebraska, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA Univ NebraskaLincoln NE USA 68583 et & Biomed Sci, Lincoln, NE 68583 USA Idec Pharmaceut Corp, San Diego, CA 92121 USA Idec Pharmaceut Corp San Diego CA USA 92121 Corp, San Diego, CA 92121 USA
Titolo Testata:
VACCINE
fascicolo: 7-8, volume: 17, anno: 1999,
pagine: 686 - 694
SICI:
0264-410X(19990226)17:7-8<686:IOMCTE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-MEDIATED-IMMUNITY; CLASS-I MOLECULES; SIMPLEX VIRUS; CONFERS PROTECTION; PEPTIDE MOTIFS; INDUCTION; RHINOTRACHEITIS; VACCINE; CYTOMEGALOVIRUS; RESPONSES;
Keywords:
allele-specific peptide motif; BHV-1; CTL epitope;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Srikumaran, S Univ68583aska, Dept Vet & Biomed Sci, Fair St & E Campus Loop, Lincoln, NE Univ Nebraska Fair St & E Campus Loop Lincoln NE USA 68583 E
Citazione:
D.S. Zatechka et al., "Identification of murine cytotoxic T-lymphocyte epitopes of bovine herpesvirus 1", VACCINE, 17(7-8), 1999, pp. 686-694

Abstract

Major histocompatibility complex (MHC) class I molecules present endogenously derived viral peptides to CD8(+) cytotoxic T-lymphocytes (CTLs). The objective of this study was to identify the H-2D(d)- and H-2K(d)-restrictcd CTL epitopes of bovine herpesvirus 1 (BHV-1). based on the allele-specific peptide motifs (ASPMs) of the above class I molecules. Nine sequences conforming to the H-2D(d) and H-2K(d) ASPMs were identified on BHV-1 proteins, and the respective peptides were synthesized. Five of these peptides exhibited moderate to strong binding to the D-d molecule. CTLs generated by BALB/c mice immunized with BHV-1 proteins emulsified in a suitable adjuvant effectively lysed peptide-pulsed syngeneic targets, indicating that these epitopes were generated in vivo. Mice immunized with these peptides emulsified in a suitable adjuvant also developed anti-BHV-1 CTLs. These CTLs identified three veritable CTL epitopes among the "potential epitopes" synthesized based on the ASPMs. The elucidation of the CTL epitopes of BHV-1 should aid in the development of efficacious vaccines against this virus. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:42:24