Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administrationwith toluene and xylene
Autore:
Chung, WG; Yu, IJ; Park, CS; Lee, KH; Roh, HK; Cha, YN;
Indirizzi:
Inha Univ, Coll Med, Dept Pharmacol, Inchon 402751, South Korea Inha UnivInchon South Korea 402751 harmacol, Inchon 402751, South Korea Inha Univ, Coll Med, Med Toxicol Res Ctr, Inchon 402751, South Korea Inha Univ Inchon South Korea 402751 Res Ctr, Inchon 402751, South Korea Inha Univ, Coll Med, Dept Internal Med, Inchon 402751, South Korea Inha Univ Inchon South Korea 402751 rnal Med, Inchon 402751, South Korea Inha Univ, Coll Med, Poison Control Ctr, Inchon 402751, South Korea Inha Univ Inchon South Korea 402751 trol Ctr, Inchon 402751, South Korea KoreaSouthSafety Corp, Ind Hlth Res Inst, Dept Ind Toxicol, Taejon 305380,Korea Ind Safety Corp Taejon South Korea 305380 Toxicol, Taejon 305380,
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-2, volume: 104, anno: 1999,
pagine: 143 - 150
SICI:
0378-4274(19990111)104:1-2<143:DFOEAF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC-SOLVENTS; METABOLISM; EXPOSURE; CYTOCHROME-P450; TOXICITY; ALCOHOL;
Keywords:
testes atrophy; ethylene glycol monoethyl ether; ethoxyacetic acid; toluene; xylene; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Cha, YN Inha Univ, Coll Med, Dept Pharmacol, Inchon 402751, South Korea Inha Univ Inchon South Korea 402751 , Inchon 402751, South Korea
Citazione:
W.G. Chung et al., "Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administrationwith toluene and xylene", TOX LETT, 104(1-2), 1999, pp. 143-150

Abstract

Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in theform of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing TOL and XYL on the EGE (200 mg/kg) on testicular atrophy and production of toxic metabolite, ethoxyacetic acid (EAA) from EGE. Compared to the extent of testes atrophy observed upon EGE administration alone, the combined administration of EGE (200 mg/kg) with TOL (250 mg/kg) andXYL (500 mg/kg) for 4 weeks has reduced the extent of testes atrophy by 25%, The combined administration delayed the time for appearance of the highest plasma concentration (t(max)) of EAA from 3 to 6 h and also decreased the highest concentration (C-max) as well as the total amount of plasma EAA (AUC(0-18) (h)) by 45 and 29%, respectively. This explained the diminished testicular atrophy in male rats observed when EGE was administered in a solvent mixture containing TOL and XYL. This study suggested that testicular toxicity observed in male painters caused by EGE may be decreased when they are exposed to EGE in the form of solvent mixture containing TOL and XYL. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:07:52