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Titolo:
The role of IL-10 in inflammatory bowel disease: "Of mice and men"
Autore:
Leach, MW; Davidson, NJ; Fort, MM; Powrie, F; Rennick, DM;
Indirizzi:
Schering Plough Corp, Res Inst, Lafayette, NJ 07848 USA Schering Plough Corp Lafayette NJ USA 07848 Inst, Lafayette, NJ 07848 USA
Titolo Testata:
TOXICOLOGIC PATHOLOGY
fascicolo: 1, volume: 27, anno: 1999,
pagine: 123 - 133
SICI:
0192-6233(199901/02)27:1<123:TROIII>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; ALPHA-MUTANT MICE; MUCOSAL IMMUNE-SYSTEM; NECROSIS-FACTOR-ALPHA; CHRONIC INTESTINAL INFLAMMATION; COMBINED IMMUNODEFICIENT MICE; PERIPHERAL-BLOOD MONOCYTES; PROPRIA MONONUCLEAR-CELLS; REFRACTORY CROHNS-DISEASE; INDUCE WASTING DISEASE;
Keywords:
interleukin-10; Th1; colitis; T cell; mucosal immunity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Leach, MW ScheringAPlough Corp, Res Inst, POB 32,144 Route 94, Lafayette, NJ 07848 US Schering Plough Corp POB 32,144 Route 94 Lafayette NJ USA 07848
Citazione:
M.W. Leach et al., "The role of IL-10 in inflammatory bowel disease: "Of mice and men"", TOX PATHOL, 27(1), 1999, pp. 123-133

Abstract

Inflammatory bowel disease (IBD) is a generic term typically used to describe a group of idiopathic inflammatory intestinal conditions in humans thatare generally divided into Crohn's disease and ulcerative colitis. Although the etiology of these diseases remains unknown, a number of rodent modelsof IBD have recently been identified, all sharing the concept that the development of chronic intestinal inflammation occurs as a consequence of alterations in the immune system that lead to a failure of normal immunoregulation in the intestine. On the basis of these models, it has been hypothesized that the development of IBD in humans may be related to a dysregulated immune response to normal flora in the gut. Immunodeficient scid mice injected with CD4(+) CD45RB(high) T cells and mice deficient in interleukin (IL)-10 (IL-10(-/-)) are among the rodent models of IBD. In both models, there isinflammation and evidence of a Th1-like response in the large intestine, characterized by CD4(+) T-cell and macrophage infiltrates, and elevated levels of interferon-gamma. Because IL-IO is an immunomodulatory cytokine that is capable of controlling Th1-like responses, the role of IL-IO was investigated in these models. IL-10 was shown to be important in regulating the development of intestinal inflammation in both models. These results providedkey data that supported initiation of clinical trials evaluating the efficacy of IL-10 in patients with IBD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:23:47