Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Granulocyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis: A prospective study
Autore:
Fukata, S; Kuma, K; Sugawara, M;
Indirizzi:
Kuma Hosp, Chuo Ku, Kobe, Hyogo 6500011, Japan Kuma Hosp Kobe Hyogo Japan6500011 p, Chuo Ku, Kobe, Hyogo 6500011, Japan Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA W Los Angeles Vet Affairs Med Ctr, Med Serv, Los Angeles, CA 90073 USA W Los Angeles Vet Affairs Med Ctr Los Angeles CA USA 90073 , CA 90073 USA W Los Angeles Vet Affairs Med Ctr, Res Serv, Los Angeles, CA 90073 USA W Los Angeles Vet Affairs Med Ctr Los Angeles CA USA 90073 , CA 90073 USA
Titolo Testata:
THYROID
fascicolo: 1, volume: 9, anno: 1999,
pagine: 29 - 31
SICI:
1050-7256(199901)9:1<29:GCF(DN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHIMAZOLE-INDUCED AGRANULOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Fukata, S Kuma Hosp, Chuo Ku, 8-2-35 Shimoyamate Dori, Kobe, Hyogo 6500011, Japan Kuma Hosp 8-2-35 Shimoyamate Dori Kobe Hyogo Japan 6500011 Japan
Citazione:
S. Fukata et al., "Granulocyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis: A prospective study", THYROID, 9(1), 1999, pp. 29-31

Abstract

Agranulocytosis is the most serious side effect of antithyroid drug (ATD) therapy. We conducted prospective and randomized studies to examine whethergranulocyte colony-stimulating factor (G-CSF) is actually effective for ATD-induced agranulocytosis. Twenty-four patients with Graves' disease who developed agranulocytosis during ATD therapy were randomly divided into a G-CSF group (n = 14) and an untreated group (n = 10). Subcutaneous injection of G-CSF (100 to 250 mu g) was given daily until neutrophil counts rose to greater than 1000/mu L. The untreated group received antibiotic therapy only. Recovery time, which is defined as the number of days required for neutrophil counts to exceed 500/mu L, was monitored by daily complete blood count(CBC). Recovery time in the G-CSF-treated group did not differ from that of the untreated group in those patients with moderate and severe agranulocytosis; thus, prolonged use of G-CSF treatment is generally ineffective for ATD-induced agranulocytosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:44:00