Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens
Autore:
Legault, M; Wise, RA;
Indirizzi:
Concordia Univ, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 31, anno: 1999,
pagine: 241 - 249
SICI:
0887-4476(19990315)31:4<241:IONITV>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; EXCITATORY AMINO-ACIDS; FREELY-MOVING RATS; LOCOMOTOR-ACTIVITY; IN-VITRO; CONDITIONED REINFORCEMENT; HYPERMOTILITY RESPONSE; ANTEROGRADE TRANSPORT; INVIVO MICRODIALYSIS; GLUTAMATE RECEPTORS;
Keywords:
microdialysis; glutamate; locomotor activity; ventral subiculum; dopamine; accumbens; VTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Legault, M Concordiantreal,Ctr Studies Behav Neurobiol, 1455 de Maisonneuve Blvd W, Mo Concordia Univ 1455 de Maisonneuve Blvd W Montreal PQ Canada H3G 1M8
Citazione:
M. Legault e R.A. Wise, "Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens", SYNAPSE, 31(4), 1999, pp. 241-249

Abstract

The nucleus accumbens septi receives inputs from dopaminergic neurons of the ventral tegmental area (VTA) and glutamatergic neurons of the ventral subiculum (VS). The convergence of these inputs in the NAS is important for the normal expression of exploratory locomotion; stimulation of the VS by injection of the glutamate receptor agonist N-methyl-D-aspartate (NMDA) causes dopamine-dependent increases in locomotion. In the present study, in vivomicrodialysis in conjunction with highperformance liquid chromatography and electrochemical detection (HPLC-EC) was used to estimate changes in extracellular dopamine in the VTA and NAS in response to intra-VS injections of NMDA (0.074, 0.28, 0.74 mu g). NMDA injections caused dose-dependent elevations in extracellular dopamine in each region. Each dose of NMDA clearly increased extracellular dopamine in the NAS, whereas only the two higher doses increased dopamine significantly in the VTA. The highest dose of NMDA elevated extracellular dopamine to approximately 180% of baseline in each region. Whereas elevations in NAS dopamine might be induced by impulse-independent local mechanisms, elevations of dopamine in the VTA are presumed to reflect increased somatodendritic release associated with increased impulse flow through dopamine neurons. Thus, the present study suggests that the modulation of dopaminergic neurotransmission by the ventral subiculum results from a trans-synaptic activation of dopamine cell bodies in the VTA. Synapse31:241-249, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:15:46