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Titolo:
Intracortical osteoblastic osteosarcoma with oncogenic rickets
Autore:
Hasegawa, T; Shimoda, T; Yokoyama, R; Beppu, Y; Hirohashi, S; Maeda, S;
Indirizzi:
Natl Canc Ctr, Res Inst, Div Pathol, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 Pathol, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Hosp, Clin Lab Div, Tokyo, Japan Natl Canc Ctr Hosp Tokyo Japan anc Ctr Hosp, Clin Lab Div, Tokyo, Japan Natl Canc Ctr Hosp, Orthoped Div, Tokyo, Japan Natl Canc Ctr Hosp Tokyo Japan anc Ctr Hosp, Orthoped Div, Tokyo, Japan Nippon Med Sch Hosp, Dept Pathol, Tokyo, Japan Nippon Med Sch Hosp TokyoJapan Med Sch Hosp, Dept Pathol, Tokyo, Japan
Titolo Testata:
SKELETAL RADIOLOGY
fascicolo: 1, volume: 28, anno: 1999,
pagine: 41 - 45
SICI:
0364-2348(199901)28:1<41:IOOWOR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSTEO-SARCOMA; OSTEOMALACIA; TUMORS;
Keywords:
tibia; intracortical osteosarcoma; osteoblastic type; calcified spherules; oncogenic rickets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hasegawa, T Natl Canc Ctr, Res Inst, Div Pathol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Natl Canc Ctr 5-1-1 Tsukiji Tokyo Japan 1040045 okyo 1040045,
Citazione:
T. Hasegawa et al., "Intracortical osteoblastic osteosarcoma with oncogenic rickets", SKELETAL RA, 28(1), 1999, pp. 41-45

Abstract

Intracortical osteosarcoma is the rarest variant of osteosarcoma, occurring within, and usually confined to, the cortical bone. Oncogenic osteomalacia, or rickets, is an unusual clinicopathologic entity in which vitamin D-resistant osteomalacia, or rickets, occurs in association with some tumors ofsoft tissue or bone. We present a case of oncogenic rickets associated with intracortical osteosarcoma of the tibia in a 9-year-old boy, whose roentgenographic abnormalities of rickets disappeared and pertinent laboratory data except for serum alkaline phosphatase became normal after surgical resection of the tumor. Histologically, the tumor was an osteosarcoma with a prominent osteoblastic pattern. An unusual microscopic feature was the presence of matrix mineralization showing rounded calcified structures (calcified spherules). Benign osteoblastic tumors, such as osteoid osteoma and osteoblastoma, must be considered in the differential diagnosis because of the relatively low cellular atypia and mitotic activity of this tumor. The infiltrating pattern with destruction or engulfment of normal bone is a major clueto the correct diagnosis of intracortical osteosarcoma. The co-existing radiographic changes of rickets were due to the intracortical osteosarcoma.

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Documento generato il 03/07/20 alle ore 00:15:04