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Titolo:
Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat
Autore:
Li, WP; Xian, C; Rush, RA; Zhou, XF;
Indirizzi:
Flinders Univ S Australia, Dept Human Physiol, Adelaide, SA 5001, Australia Flinders Univ S Australia Adelaide SA Australia 5001 , SA 5001, Australia Flinders Univ S Australia, Ctr Neurosci, Adelaide, SA 5001, Australia Flinders Univ S Australia Adelaide SA Australia 5001 , SA 5001, Australia Womens & Childrens Hosp, Child Hlth Res Inst, Adelaide, SA, Australia Womens & Childrens Hosp Adelaide SA Australia t, Adelaide, SA, Australia
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 260, anno: 1999,
pagine: 49 - 52
SICI:
0304-3940(19990122)260:1<49:UOBNFA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS; IMMUNOREACTIVITY; EXPRESSION; AXOTOMY; BDNF;
Keywords:
brain-derived neurotrophic factor; neuropeptide Y; sciatic nerve injury; gracile nucleus; dorsal root ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Zhou, XF Flinders001,v S Australia, Dept Human Physiol, GPO Box 2100, Adelaide, SA 5 Flinders Univ S Australia GPO Box 2100 Adelaide SA Australia 5001
Citazione:
W.P. Li et al., "Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat", NEUROSCI L, 260(1), 1999, pp. 49-52

Abstract

An immunohistochemical study was undertaken to examine the changes of brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) in the nucleus gracilis of rats following sciatic nerve transection. The results showed that BDNF-immunoreactivity (-ir) in the gracile nucleus was significantly increased after the nerve injury. The upregulation was apparent 24 h after nerve lesion, remaining robust up to 56 days postlesion. The increase in BDNF-ir was blocked by hemisection of the spinal cord, or by dorsal rhizotomy ipsilateral to the lesion. NPY-ir changes were similar to those of BDNF-ir,but the onset was delayed;by 7 days. No NPY-ir was detected in dorsal rootganglion (DRG) from normal animals. Following sciatic nerve lesion, most of the NPY-immunoreactive neurones were found to be colocalized with BDNF-immunoreactive neurones. Neutralization of endogenous BDNF with its antiserumhad no effects on NPY-ir in either the gracile nucleus or DRG. These results indicate that neurones contributing to the dorsal ascending sensory pathway upregulate the expression of both BDNF and NPY in response to sciatic nerve injury. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:09:50