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Titolo:
HEMODYNAMIC-RESPONSE TO ADENOSINE INFUSION BEFORE AND AFTER CORONARY-ARTERY BYPASS-SURGERY
Autore:
ANDERSON RE; LIND B; OWALL A; BRODIN LA;
Indirizzi:
KAROLINSKA HOSP,DEPT CARDIOTHORAC ANAEXTHET & INTENS CARE S-10401 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT CLIN PHYSIOL S-10401 STOCKHOLM SWEDEN
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 3, volume: 29, anno: 1997,
pagine: 331 - 336
SICI:
0160-2446(1997)29:3<331:HTAIBA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TWO-DIMENSIONAL ECHOCARDIOGRAPHY; INDUCED HYPOTENSION; MYOCARDIAL PERFUSION; ANEURYSM SURGERY; GRAFT-SURGERY; DOBUTAMINE; METABOLISM; MOTION; STRESS; VOLUME;
Keywords:
ADENOSINE; CORONARY ARTERY BYPASS SURGERY; HEMODYNAMICS; MYOCARDIAL EJECTION FRACTION; DOPPLER ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Anderson et al., "HEMODYNAMIC-RESPONSE TO ADENOSINE INFUSION BEFORE AND AFTER CORONARY-ARTERY BYPASS-SURGERY", Journal of cardiovascular pharmacology, 29(3), 1997, pp. 331-336

Abstract

This study describes the hemodynamic dose-response characteristics ofa titrated, continuous adenosine infusion before and 1 h (anesthetized), 1 week, and 1 year after coronary artery bypass graft (CABG) surgery. Average tolerated adenosine infusion rates were less 1 h and 1 week after surgery (128 +/- 23 and 118 +/- 27 mu g/kg/min, respectively) than before (156 +/- 29 mu g/kg/min) and 1 year after surgery (156 +/-24 mu g/kg/min). Heart rate (HR) increased with a 120-mu g/kg/min adenosine infusion rate both preoperatively (21 +/- 11%) and 1 year postoperatively (16 +/- 8%). Systolic blood pressure (BP) decreased 26 +/- 11%, 14 +/- 7%, and 9 +/- 6% with 120 mu g/kg/min adenosine for the three postoperative examinations. The integral of the outflow tract velocity with 120 mu g/kg/min adenosine increased 49 +/- 22% and 29 +/- 12% after 1 h and 1 week, respectively, whereas its product with HR increased equally for all examinations (40 +/- 22%, 62 +/- 27%, 46 +/- 13%, and 39 +/- 11%). The average preoperative left ventricular area shortening was 45 +/- 10% and neither it nor end-diastolic left ventricular area (preload) changed with surgery, time after surgery, or with adenosine. A titrated adenosine infusion is well suited to patients requiring a pharmacologic provocation to expose reversible myocardial ischemia during the first hours or days after CABG surgery. The anesthetized and anemic patient are particularly unsuited for the commonly used fixed-infusion-rate protocol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:04:30