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Titolo:
Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: A study with functional magnetic resonance imaging
Autore:
Schroder, J; Essig, M; Baudendistel, K; Jahn, T; Gerdsen, I; Stockert, A; Schad, LR; Knopp, MV;
Indirizzi:
Univ Heidelberg, Dept Psychiat, Heidelberg, Germany Univ Heidelberg Heidelberg Germany , Dept Psychiat, Heidelberg, Germany German Canc Res Ctr, Dept Radiol, D-6900 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-6900 D-6900 Heidelberg, Germany Univ Konstanz, Dept Psychol, D-7750 Constance, Germany Univ Konstanz Constance Germany D-7750 sychol, D-7750 Constance, Germany
Titolo Testata:
NEUROIMAGE
fascicolo: 1, volume: 9, anno: 1999,
pagine: 81 - 87
SICI:
1053-8119(199901)9:1<81:MDASCA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINGER MOVEMENT; 1.5 T; AREAS;
Keywords:
neurological soft signs; schizophrenia; functional magnetic resonance imaging; sensorimotor cortex; supplementary motor area;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Schroder, J Univ Heidelberg, Dept Psychiat, Bergheimer Str 58, Heidelberg,Germany Univ Heidelberg Bergheimer Str 58 Heidelberg Germany Germany
Citazione:
J. Schroder et al., "Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: A study with functional magnetic resonance imaging", NEUROIMAGE, 9(1), 1999, pp. 81-87

Abstract

Recent studies demonstrate a diminished activation of the sensorimotor cortex and supplementary motor area (SMA) in schizophrenia which may be involved in the pathogenesis of neurological soft signs (NSS). Yet, the question whether a retarded motor performance may account for these changes remainedto be clarified. Twelve DSM-III-R schizophrenics and 12 healthy controls were included. All subjects were right-handed. Nine patients received clozapine, two conventional neuroleptics, and one was drug-free. Functional magnetic resonance imaging (fMRI) was obtained in a resting condition and duringpronation/supination at three speed levels (low, medium, and high) with motor performance recorded simultaneously using a pronation/supination device. While measures of motor retardation (i.e., repetition rate and amplitude of the movements) did not differ between patients and controls, the variability of performance was significantly (P < 0.05) increased in the patients'group. In addition, patients with schizophrenia showed a significantly (P < 0.05) decreased activation of the sensorimotor cortices. Similar, although nonsignificant (P = 0.09) activation changes were observed in the SMA. Activation differences were more pronounced at a slow speed and in the drug-free patient. These results confirm a diminished sensorimotor cortex and SMAactivation and indicate that variability of performance rather than retarded performance per se may correspond to these changes. (C) 1999 Academic Press.

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Documento generato il 02/04/20 alle ore 18:45:06