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Titolo:
Effect of gender differences and estrogen replacement therapy on vascular reactivity
Autore:
Perregaux, D; Chaudhuri, A; Mohanty, P; Bukhari, L; Wilson, MF; Sung, BH; Dandona, P;
Indirizzi:
Stateuffalo,sity New York Buffalo, Millard Fillmore Hosp, Div Endocrinol, B State University New York Buffalo Buffalo NY USA 14209 Div Endocrinol, B Stateo,niversity New York Buffalo, Millard Fillmore Hosp, Div Metab, Buffal State University New York Buffalo Buffalo NY USA 14209 Div Metab, Buffal Statealo,versity New York Buffalo, Millard Fillmore Hosp, Div Cardiol, Buff State University New York Buffalo Buffalo NY USA 14209 Div Cardiol, Buff
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 48, anno: 1999,
pagine: 227 - 232
SICI:
0026-0495(199902)48:2<227:EOGDAE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL NITRIC-OXIDE; DEPENDENT DIABETES-MELLITUS; CORONARY-ARTERY DISEASE; POSTMENOPAUSAL WOMEN; VASODILATION; INSULIN; STIMULATION; DYSFUNCTION; MECHANISMS; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Dandona, P State University New York Buffalo, Millard Fillmore Hosp, Div Endocrinol, 3 State University New York Buffalo 3 Gates Circle Buffalo NY USA 14209
Citazione:
D. Perregaux et al., "Effect of gender differences and estrogen replacement therapy on vascular reactivity", METABOLISM, 48(2), 1999, pp. 227-232

Abstract

The incidence of cardiovascular disease is lower in premenopausal women compared with men; following menopause, the risk of mortality from cardiovascular disease increases in females. Postischemic dilatation of the brachial artery has been used previously as an index of endothelium-mediated vasodilation. Using this index, we examined a group of premenopausal and postmenopausal women, some of whom were on estrogen replacement therapy (ERT). All subjects were normotensive (blood pressure [BP] < 140/90 mm Hg) and normoglycemic (blood glucose, < 100 mg/dL). Fourteen healthy women (mean age, 27 +/- 0.8 years; mean total cholesterol, 174 +/- 6.7 mg/dL) and fourteen healthy men (mean age, 26 +/- 1.4 years; mean total cholesterol, 181 +/- 7.2 mg/dL) were investigated. Nineteen postmenopausal women were also examined; 11 were on ERT (mean age, 55 +/- 2.1 years; mean total cholesterol, 213 +/- 6.6 mg/dL) and eight were not on ERT (mean age, 60 +/- 3.6 years; mean total cholesterol, 222 +/- 14.4 mg/dL). Ischemia was induced by inflating a cuff over the forearm to a pressure of 40 mm Hg above systolic for 5 minutes. Doppler ultrasonography (Acuson [Mountain View, CA] 128XP/10c ultrasonograph with a 7.5-MHz linear array transducer) was used to measure the brachial artery diameter before inflation and 15 seconds and 45 to 60 seconds following cuff deflation. Flow-mediated dilatation (FMD%) and hyperemia were defined as the percentage increase over basal diameter and basal flow, respectively. Postischemic median dilatation in men was 4.20% (interquartile range, 2.13% to 5.56%) and 11.48% (interquartile range, 8.70% to 14.29%) in age-matched premenopausal women (P < .01). For women on ERT, the postischemic median dilatation was 8.11% (interquartile range, 6.01% to 11.60%), as comparedwith 2.82% (interquartile range, 1.32% to 3.28%) for women without ERT (P < .01). Premenopausal women showed significantly greater dilatation after ischemia than postmenopausal women without ERT (P < .0001). Hyperemia was similar in all groups. These findings show that postischemic vasodilation of the brachial artery is greater in premenopausal women versus age-matched men; it is decreased in postmenopausal women, and ERT restores it toward normal. The pathophysiology underlying the diminution in postischemic dilatation may be relevant to atherogenesis and coronary artery disease (CAD). Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:08:51