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Titolo:
CHICKEN INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP)-5 - CONSERVATION OF IGFBP-5 STRUCTURE AND EXPRESSION DURING EVOLUTION
Autore:
ALLANDER SV; COLEMAN M; LUTHMAN H; POWELL DR;
Indirizzi:
BAYLOR COLL MED,TEXAS CHILDRENS HOSP,CLIN CARE CTR,MC3-2482,6621 FANNIN HOUSTON TX 77030 BAYLOR COLL MED,DEPT PEDIAT HOUSTON TX 77030 BAYLOR COLL MED,DEPT CELL BIOL HOUSTON TX 77030 KAROLINSKA INST,DEPT MOL MED S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Comparative biochemistry and physiology. B. Comparative biochemistry
fascicolo: 4, volume: 116, anno: 1997,
pagine: 477 - 483
SICI:
0305-0491(1997)116:4<477:CIGB(->2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENOL-CHLOROFORM EXTRACTION; HUMAN CHROMOSOMAL GENE; SINGLE-STEP METHOD; MOLECULAR-CLONING; MYOBLAST DIFFERENTIATION; PROMOTER REGION; RNA ISOLATION; FACTOR CDNA; FACTOR-II; RAT;
Keywords:
INSULIN-LIKE GROWTH FACTORS (IGFS); INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS (IGFBPS); INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-5 (IGFBP-5); CHICKEN; VERTEBRATES; MYOBLAST; DIFFERENTIATION; EMBRYONIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S.V. Allander et al., "CHICKEN INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP)-5 - CONSERVATION OF IGFBP-5 STRUCTURE AND EXPRESSION DURING EVOLUTION", Comparative biochemistry and physiology. B. Comparative biochemistry, 116(4), 1997, pp. 477-483

Abstract

A complementary DNA (cDNA) clone encoding chicken insulin-like growthfactor binding protein 5 (cIGFBP-5) was isolated. The nucleotide sequence of the 1236-bp clone encodes a mature polypeptide of 251 amino acids with a calculated molecular weight of approximately 28.2 kDa. The deduced amino acid sequence is 83% identical to human IGFBP-5. LabeledcIGFBP-5 cDNA detected a single mRNA transcript of similar to 6 kb byNorthern blot analysis of various tissues obtained from embryonic and6 weeks post-hatch chickens; interestingly, adult heart showed an similar to 10-fold increase in cIGFBP-5 mRNA relative to embryonic heart. The pattern of IGFBP-5 mRNA expression in chicken tissues was similarto that found in mammals during fetal and extrauterine life. In addition, IGFBP-5 mRNA was abundant in primary cultures of chicken myoblasts throughout in vitro differentiation and fusion. The conservation of IGFBP-5 primary structure and expression pattern across vertebrate species suggests conservation of important functions during evolution, particularly in muscle differentiation. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:44:02