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Titolo:
Spinal administration of selective opioid antagonists in amphibians: Evidence for an opioid unireceptor
Autore:
Stevens, CW; Newman, LC;
Indirizzi:
OSU, COM, Dept Pharmacol & Physiol, Tulsa, OK 74107 USA OSU Tulsa OK USA 74107 COM, Dept Pharmacol & Physiol, Tulsa, OK 74107 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 10, volume: 64, anno: 1999,
pagine: PL125 - PL130
SICI:
0024-3205(19990129)64:10<PL125:SAOSOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-DEPENDENT ANTAGONISM; RECEPTOR SUBTYPES; ANALGESIC POTENCY; BINDING-SITES; AGONISTS; BRAIN; FROG; NALTRINDOLE; EVOLUTION; PEPTIDES;
Keywords:
opioid antinociception; morphine; opioid receptor; amphibian; unireceptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Stevens, CW OSU, COM, Dept Pharmacol & Physiol, 1111 W 17th St, Tulsa, OK 74107 USA OSU 1111 W 17th St Tulsa OK USA 74107 St, Tulsa, OK 74107 USA
Citazione:
C.W. Stevens e L.C. Newman, "Spinal administration of selective opioid antagonists in amphibians: Evidence for an opioid unireceptor", LIFE SCI, 64(10), 1999, pp. PL125-PL130

Abstract

In mammals, opioids act by interactions with three distinct types of receptors: mu, delta, or kappa opioid receptors. Using a novel assay of antinociception in the Northern grass frog, Rana pipiens, previous work demonstrated that selective mu, delta, or kappa opioids produced a potent antinociception when administered by the spinal route. The relative potency of this effect was highly correlated to that found in mammals. Present studies employing selective opioid antagonists, beta-FNA, NTI, or nor-BNI demonstrated that, in general, these antagonists were not selective in the amphibian model. These data have implications for the functional evolution of opioid receptors in vertebrates and suggest that the tested mu, delta, and kappa opioidsmediate antinociception via a single type of opioid receptor in amphibians, termed the unireceptor. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:25:55