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Titolo:
IgE multiple myeloma
Autore:
Macro, M; Andre, I; Comby, E; Cheze, S; Chapon, F; Ballet, JJ; Reman, O; Leporrier, M; Troussard, X;
Indirizzi:
CHU Caen, Dept Clin Haematol, F-14000 Caen, France CHU Caen Caen France F-14000 n, Dept Clin Haematol, F-14000 Caen, France
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 32, anno: 1999,
pagine: 597 - 603
SICI:
1042-8194(1999)32:5-6<597:IMM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL IGE; BONE DENSITOMETRY; RENAL-FAILURE; GAMMOPATHY; DISEASE; LESIONS;
Keywords:
bone densitometry; IgE; multiple myeloma; magnetic resonance imaging; osteoporosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Macro, M CHU Clemenceau, Dept Clin Haematol, F-14000 Caen, France CHU Clemenceau Caen France F-14000 ematol, F-14000 Caen, France
Citazione:
M. Macro et al., "IgE multiple myeloma", LEUK LYMPH, 32(5-6), 1999, pp. 597-603

Abstract

IgE multiple myeloma is a rare disease characterized by a high frequency of Bence-Jones pro teinuria and plasma cell leukaemia when compared to otherisotypes of monoclonal proteins. Only 35 cases have been reported. We describe a 70-year-old woman with a stage III IgE kappa multiple myeloma presenting with a sacral plasmacytoma. Immunological and biochemical studies showed IgE kappa producing tumoral plasma cells. Serum total IgE was high without clinical symptoms suggesting an hyperIgE syndrome or mast cell activation. The patient underwent surgical removal of the sacral tumor and monthly melphalan-prednisone treatment together with intravenous pamidronate infusions. Magnetic Resonance Imaging (MRI) of the dorsolumbar spine revealed an epidural process leading to T6-T9 radio-therapy. Bone densitometry showed a decreased bone mineral content supporting the management of myeloma-relatedosteoporosis with bisphosphonate infusions. A good partial response with plateau-phase and increase of bone mineral content was achieved after 1 year of treatment and still persists after a 28 months follow-up.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:56:18