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Titolo:
Angioimmunoblastic-like T-cell non Hodgkin's lymphoma: Outcome after chemotherapy in 33 patients and review of the literature
Autore:
Pautier, P; Devidas, A; Delmer, A; Dombret, H; Sutton, L; Zini, JM; Nedelec, G; Molina, T; Marolleau, JP; Brice, P;
Indirizzi:
Hop St Louis, HDJ Hematol, F-75475 Paris 10, France Hop St Louis Paris France 10 ouis, HDJ Hematol, F-75475 Paris 10, France
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 32, anno: 1999,
pagine: 545 - 552
SICI:
1042-8194(1999)32:5-6<545:ATNHLO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; BARR-VIRUS INFECTION; PROGNOSTIC FACTORS; INTERFERON-ALPHA; DYSPROTEINEMIA; PATTERNS; REGIMEN;
Keywords:
angioimmunoblastic T-cell lymphoma; chemotherapy; interferon alpha; high-dose chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Brice, P Hop St Louis, HDJ Hematol, 1 Ave Claude Vellefaux, F-75475 Paris 10, France Hop St Louis 1 Ave Claude Vellefaux Paris France 10 s 10, France
Citazione:
P. Pautier et al., "Angioimmunoblastic-like T-cell non Hodgkin's lymphoma: Outcome after chemotherapy in 33 patients and review of the literature", LEUK LYMPH, 32(5-6), 1999, pp. 545-552

Abstract

We analyzed 33 patients with AILD T-NHL in a retrospective multicentric study. The median age was 62 yr (35-84 yr) (19 patients over 60 yr), Advanceddisease (n = 31) and B-symptoms were consistently found (n = 29) and 20 patients had bone marrow involvement, The main laboratory abnormalities were:anemia (n = 13), hypereosinophilia (n = 13), lymphopenia (n = 14), hypergammaglobulinemia (n = 17), elevated lactate dehydrogenase (LDH) level (n = 24). First-line therapy was chemotherapy (ChT) alone (n = 25) or ChT after steroids (n = 8). Most patients received a CHOP-like regimen for a median number of 6 cycles and 3 patients received interferon alpha (IFN alpha) as consolidation after chemotherapy. With a median follow-up of 46 mo, 60% achieved a complete response but the outcome was poor with a relapse rate at 56%, a median survival referring to the total population was of 36 mo (2-108+ mo) and an overall survival at 5 yr of 36%. Two patients received high-dosechemotherapy (with total body irradiation) and autologous progenitor-cell transplantation for chemosensitive relapse and were free of disease at, respectively, 76 and 24 mo+, In conclusion AILD T-NHL still has a poor prognosis compared to other NHL. The role of intensive therapy and IFN alpha stillremains to be evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:29:58