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Titolo:
Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue
Autore:
Tarcan, T; Park, K; Goldstein, I; Maio, G; Fassina, A; Krane, RJ; Azadzoi, KM;
Indirizzi:
Boston Univ, Sch Med, Dept Urol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Sch Med, Dept Urol, Boston, MA 02118 USA Casa Cura Abano Terme, Unit Urol, Padua, Italy Casa Cura Abano Terme Padua Italy Abano Terme, Unit Urol, Padua, Italy Univ Padua, Sch Med, Dept Pathol, I-35100 Padua, Italy Univ Padua Padua Italy I-35100 ch Med, Dept Pathol, I-35100 Padua, Italy Boston VA Med Ctr, Dept Urol, Boston, MA 02130 USA Boston VA Med Ctr Boston MA USA 02130 tr, Dept Urol, Boston, MA 02130 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 3, volume: 161, anno: 1999,
pagine: 940 - 944
SICI:
0022-5347(199903)161:3<940:HAOASC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEXUAL FUNCTION; DYSFUNCTION; MECHANISMS;
Keywords:
clitoris; age; fibrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Azadzoi, KM BostonUSA Med Ctr, Dept Urol, B5-45,150 S Huntington Ave, Boston, MA 02130 Boston VA Med Ctr B5-45,150 S Huntington Ave Boston MA USA 02130
Citazione:
T. Tarcan et al., "Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue", J UROL, 161(3), 1999, pp. 940-944

Abstract

Purpose: To characterize age-associated histological changes of human clitoral cavernosal tissue and to determine whether age-related histological changes of clitoral cavernosal tissue correlate with vascular disease-relatedmortality. Materials and Methods: Human clitorises were Obtained from 15 fresh cadavers (age: 11 to 90 years) and from 3 patients undergoing clitoral surgery (age: 6 months to 15 years). Cross sections of the clitorises were stained with Masson's trichrome and utilized for computer assisted histomorphometric image analysis to determine the clitoral cavernosal content of smooth muscle and connective tissue. Results: These studies revealed a strong link, between increase in age anddecreased clitoral cavernosal smooth muscle fibers. In histomorphometry, the percentage of clitoral cavernosal. smooth muscle (mean +/- standard error) in an age group of 6 months to 15 years (n = 4) was 65 +/- 1.5, in 44 to54 years (n = 7) was 50 +/- 1.2, and in 55 to 90 years (n = 7) was 37 +/- 1.3 (ANOVA, p = 0.0001). In the 18 tissues studied, decrease in the percentage of clitoral cavernosal smooth muscle significantly correlated with increase in age (simple regression, r = 0.61). In the age group of 44 to 90 years, clitoral cavernosal fibrosis was significantly greater in the presence of cardiovascular disease-related mortality compared with those without cardiovascular disease-related mortality. Conclusion: This study shows that aging women undergo histological changesin clitoral cavernosal erectile tissue. Vascular risk factors may adversely affect the structure of clitoral cavernosal tissue. These findings may beof importance in the pathophysiology of age-associated female sexual arousal disorders.

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Documento generato il 24/11/20 alle ore 11:20:50