Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): Evaluation by noninvasive tissue oximetry
Autore:
Abe, K; Matsuo, Y; Kadekawa, J; Inoue, S; Yanagihara, T;
Indirizzi:
Osaka Univ, Grad Sch, Dept Neurol, Suita, Osaka 565, Japan Osaka Univ Suita Osaka Japan 565 ch, Dept Neurol, Suita, Osaka 565, Japan Osaka Univ Hosp, Rehabil Unit, Osaka 553, Japan Osaka Univ Hosp Osaka Japan 553 niv Hosp, Rehabil Unit, Osaka 553, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 162, anno: 1999,
pagine: 65 - 68
SICI:
0022-510X(19990101)162:1<65:EOCQIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENCEPHALOMYOPATHY; DEFICIENCY; SPECTROSCOPY; THERAPY;
Keywords:
coenzyme q10; tissue oximetry; near-infrared spectra of hemoglobin; mitochondrial myopathy; encephalopathy; lactic acidosis; stroke-like episodes (MELAS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, K Osaka Univ, Grad Sch, Dept Neurol, 2-2 Yamadaoka, Suita, Osaka 565,Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 565 ta, Osaka 565, Japan
Citazione:
K. Abe et al., "Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): Evaluation by noninvasive tissue oximetry", J NEUR SCI, 162(1), 1999, pp. 65-68

Abstract

We evaluated the effect of coenzyme Q10 supplementation to two patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-likeepisodes (MELAS) by using noninvasive tissue oximetry with near-infrared spectra of hemoglobin from the quadriceps muscle during bicycle ergometer exercise. Patients showed distinct oxygen consumption patterns reflecting thedefect in oxidative phosphorylation and the impairment in oxygen utilization during exercise. Based on the oxygen consumption pattern, we considered one patient as having severe mitochondrial disorder and another patient as having mild one. After coenzyme Q10 supplementation, the oxygen consumptionpattern of the patient with the severe form shifted to the mild one, whilethat of the patient with mild form remained unchanged. The shift of the pattern to the mild form correlated well with reduction of the sum of the serum lactate and pyruvate content during exercise. Noninvasive tissue oximetry may be useful to evaluate the effect of coenzyme Q10 supplementation to patients with mitochondrial encephalomyopathy including MELAS. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:34:04