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Titolo:
Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography: application to therapeutic drug monitoring in Japanese patients with schizophrenia
Autore:
Nagasaki, T; Ohkubo, T; Sugawara, K; Yasui, N; Furukori, H; Kaneko, S;
Indirizzi:
Hirosaki Univ Hosp, Dept Pharm, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hosp Hirosaki Aomori Japan 0368563 i, Aomori 0368563, Japan Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hirosaki Aomori Japan 0368563 rosaki, Aomori 0368563, Japan
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 3-4, volume: 19, anno: 1999,
pagine: 595 - 601
SICI:
0731-7085(199903)19:3-4<595:DORA9I>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROCHEMICAL DETECTION; SERUM;
Keywords:
risperidone; 9-hydroxyrisperidone; high-performance-liquid-chromatography; schizophrenia; steady-state plasma concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Ohkubo, T Hirosaki Univ Hosp, Dept Pharm, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hosp Hirosaki Aomori Japan 0368563 0368563, Japan
Citazione:
T. Nagasaki et al., "Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography: application to therapeutic drug monitoring in Japanese patients with schizophrenia", J PHARM B, 19(3-4), 1999, pp. 595-601

Abstract

A high-performance liquid chromatographic method has been developed for the simultaneous determination of risperidone and its major active metabolite9-hydroxyrisperidone in plasma. Risperidone and 9-hydroxyrisperidone in plasma were extracted using a CN bonded-solid phase cartridge, followed by, C4 reversed-phase HPLC separation. Risperidone, 9-hydroxyrisperidone and trazodone as an internal standard were detected by ultraviolet absorbance at 280 nm. It was possible to determine risperidone in the concentration range of 1.0-100.0 ng ml(-1) and 9-hydroxyrisperidone at a range of 2.0-200.0 ng ml(-1). The detection limits of risperidone and 9-hydroxyrisperidone were 0.5 and 1.0 ng ml(-1), respectively. The mean recoveries of risperidone and 9-hydroxyrisperidone added to plasma were less than 92.0 and 92.6%, with a coefficient of variation of less than 10.6 and 10.5%, respectively. This method has been used for the simultaneous determination of steady-state plasma concentration (Css) of risperidone and 9-hydroxyrisperidone in schizophrenic patients treated with 3-, 6-, and 12-mg risperidone oral doses per day. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:00:09