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Titolo:
Determination of silymarine in the extract from the dried silybum marianumfruits by high performance liquid chromatography and capillary electrophoresis
Autore:
Quaglia, MG; Bossu, E; Donati, E; Mazzanti, G; Brandt, A;
Indirizzi:
Univ La Sapienza, Dipartimento Studi Farmaceut, I-00185 Rome, Italy Univ La Sapienza Rome Italy I-00185 Studi Farmaceut, I-00185 Rome, Italy Univ La Sapienza, Ist Farmacol & Farmacognosia, I-00185 Rome, Italy Univ La Sapienza Rome Italy I-00185 & Farmacognosia, I-00185 Rome, Italy Ist Biochim Italiano, Lab Aprlia, I-04011 Aprila, LT, Italy Ist Biochim Italiano Aprila LT Italy I-04011 a, I-04011 Aprila, LT, Italy
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 3-4, volume: 19, anno: 1999,
pagine: 435 - 442
SICI:
0731-7085(199903)19:3-4<435:DOSITE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE ASPECTS; PLASMA; SILIBININ;
Keywords:
high performance liquid chromatography; high performance capillary electrophoresis; determination of silymarine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Quaglia, MG Univ La Sapienza, Dipartimento Studi Farmaceut, Ple A Moro 5, I-00185 Rome, Univ La Sapienza Ple A Moro 5 Rome Italy I-00185 -00185 Rome,
Citazione:
M.G. Quaglia et al., "Determination of silymarine in the extract from the dried silybum marianumfruits by high performance liquid chromatography and capillary electrophoresis", J PHARM B, 19(3-4), 1999, pp. 435-442

Abstract

Silybine (SBN), isosilybine (ISBN), silycristine (SCN), silydianine (SDN),and taxifoline (TXF) are the main active flavanoids, generally found in the dried fruits of silybum marianum. The concentrations of these compounds, excepted TXF, are all together usually expressed as silymarine content. In this paper the determination of the silymarine titre was made by high performance liquid chromatography (HPLC), and high performance capillary electrophoresis (HPCE). Two reversed stationary phases, RP-18 and RP-8, were observed comparing the resolutions of all considered flavanoids with each stationary phases. The HPCE was carried out considering the possible improvement in the resolution of SBN, CN, SDN and TXF using,8-cyclodextrines or organicmodifier. The qualitative and quantitative data obtained by HPLC and HPCE were compared. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:16:44