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Titolo:
High levels in serum, but no signs of intrathecal synthesis of anti-sulfatide antibodies in HIV-1 infected individuals with or without central nervous system complications
Autore:
Gisslen, M; Lekman, A; Fredman, P;
Indirizzi:
Sahlgrens,Univ Hosp, Inst Internal Med, Dept Infect Dis, S-41685 Gothenburg Sahlgrens Univ Hosp Gothenburg Sweden S-41685 ct Dis, S-41685 Gothenburg Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Psychiat & Neurochem, S-41345 Sahlgrens Univ Hosp Gothenburg Sweden S-41345 chiat & Neurochem, S-41345
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 94, anno: 1999,
pagine: 153 - 156
SICI:
0165-5728(19990201)94:1-2<153:HLISBN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS DEMENTIA COMPLEX; CEREBROSPINAL-FLUID; NEUROLOGICAL DISORDERS; REACTION-TIME; MARKERS; MYELIN; IGG; PROTEINS;
Keywords:
HIV; cerebrospinal fluid; serum; anti-sulfatide antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gisslen, M Sahlgrens,Univ Hosp, Inst Internal Med, Dept Infect Dis, S-41685 Gothenburg Sahlgrens Univ Hosp Gothenburg Sweden S-41685 1685 Gothenburg
Citazione:
M. Gisslen et al., "High levels in serum, but no signs of intrathecal synthesis of anti-sulfatide antibodies in HIV-1 infected individuals with or without central nervous system complications", J NEUROIMM, 94(1-2), 1999, pp. 153-156

Abstract

Myelin degeneration is commonly found in the central nervous system (CNS) of individuals infected with human immunodeficiency virus type 1 (HIV-1), especially in patients with HIV-1-associated dementia. We analysed cerebrospinal fluid (CSF) and serum samples from 25 HIV-1 infected individuals for the presence of antibodies directed against sulfatide, the major acidic glycosphingolipid in myelin. Nine of the patients had CNS complications, including 3 with HIV-1-associated dementia, and 16 had no neurological symptoms. Elevated titres of anti-sulfatide antibodies were found in serum from 24/25HIV-1-infected individuals but in none of them in the CSF. Although the vast majority of HIV-1-infected individuals harbour autoantibodies directed against sulfatide in serum, the lack of detectable intrathecal production indicates that anti-sulfatide antibodies are not a major component in the pathogenesis of CNS myelin damage in HIV-1 infection. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:55:25