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Titolo:
Premalignant lesions and hepatocellular carcinoma in a non-cirrhotic alcoholic patient with iron overload and normal transferrin saturation
Autore:
Blanc, JF; De Ledinghen, V; Trimoulet, P; Le Bail, B; Bernard, PH; Saric, J; Balabaud, C; Bioulac-Sage, P;
Indirizzi:
Univ Bordeaux 2, Grp Rech Etude Foie, Pathol Lab, F-33076 Bordeaux, FranceUniv Bordeaux 2 Bordeaux France F-33076 ol Lab, F-33076 Bordeaux, France Hop St Andre, Federat Hepatol Gastroenterol, Bordeaux, France Hop St Andre Bordeaux France at Hepatol Gastroenterol, Bordeaux, France CHU Bordeaux, Hop Pellegrin, Virol Lab, Bordeaux, France CHU Bordeaux Bordeaux France Hop Pellegrin, Virol Lab, Bordeaux, France CHU Bordeaux, Hop Pellegrin, Serv Anat Pathol, Bordeaux, France CHU Bordeaux Bordeaux France legrin, Serv Anat Pathol, Bordeaux, France
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 2, volume: 30, anno: 1999,
pagine: 325 - 329
SICI:
0168-8278(199902)30:2<325:PLAHCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROREGENERATIVE NODULES; GENETIC HEMOCHROMATOSIS; LIVER; HEPATOCARCINOGENESIS; FOCI;
Keywords:
C282Y+/- mutation; dysplastic nodules; hepatocellular carcinoma; hyperplastic nodules; iron-free foci; non-cirrhotic liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bioulac-Sage, P Univ Bordeaux 2, Grp Rech Etude Foie, Pathol Lab, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 Bordeaux, France
Citazione:
J.F. Blanc et al., "Premalignant lesions and hepatocellular carcinoma in a non-cirrhotic alcoholic patient with iron overload and normal transferrin saturation", J HEPATOL, 30(2), 1999, pp. 325-329

Abstract

A 66-year-old white man had a hepatic resection for a 6-cm well-differentiated hepatocellular carcinoma which had developed in a non-cirrhotic liver. The only risk factors found were heavy drinking, smoking and heterozygosity for the C282Y mutation of the HFE gene, The liver was mildly fibrotic andoverloaded with iron. It also contained numerous iron-free hepatocellular lesions from <1 to 10 mm, suggesting a premalignant change. These lesions were of three types: (i) iron-free foci, (ii) hyperplastic nodules and (iii)dysplastic nodules with severe dysplasia or even foci of well-differentiated grade I hepatocellular carcinoma. This observation suggests the possibility of malignant transformation of the liver in the newly-described syndrome of iron overload and normal transferrin saturation. It also illustrates the multistep process of carcinogenesis in the non-cirrhotic liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:46:04