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Titolo:
Effects of calcium supplementation on calcium homeostasis and bone turnover in lactating women
Autore:
Kalkwarf, HJ; Specker, BL; Ho, M;
Indirizzi:
ChildrensSAosp, Med Ctr, Div Gen & Community Pediat, Cincinnati, OH 45229 U Childrens Hosp Cincinnati OH USA 45229 ity Pediat, Cincinnati, OH 45229 U S Dakota State Univ, EA Martin Program Human Nutr, Brookings, SD 57007 USAS Dakota State Univ Brookings SD USA 57007 Nutr, Brookings, SD 57007 USA Univ45267innati, Med Ctr, Inst Hlth Policy & Hlth Serv Res, Cincinnati, OHUniv Cincinnati Cincinnati OH USA 45267 y & Hlth Serv Res, Cincinnati, OH
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 84, anno: 1999,
pagine: 464 - 470
SICI:
0021-972X(199902)84:2<464:EOCSOC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELATED PEPTIDE; PARATHYROID-HORMONE; MINERAL DENSITY; URINARY CALCIUM; SERUM 1,25-DIHYDROXYVITAMIN-D; POSTPARTUM WOMEN; HUMAN-PREGNANCY; PLASMA-LEVELS; METABOLISM; PHOSPHATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kalkwarf, HJ Childrensnnati, Med Ctr, Div Gen & Community Pediat, 3333 Burnet Ave, Cinci Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 Cinci
Citazione:
H.J. Kalkwarf et al., "Effects of calcium supplementation on calcium homeostasis and bone turnover in lactating women", J CLIN END, 84(2), 1999, pp. 464-470

Abstract

Lactation is a time of calcium flux, because women secrete approximately 210 mg calcium/day in breast milk, and they experience a transient bone loss. The objectives of this study were to determine the effect of calcium supplementation on adaptive responses in calcium homeostasis during lactation and after weaning. Two cohorts of women participated in a 6-month randomizedcalcium supplementation trial. Lactation cohort women (97 lactating, 99 nonlactating) were studied during the first 6 months post pal-rum, and weaning cohort women (95 lactating, 92 nonlactating) were studied during the second 6 months post partum. Lactating women in the weaning cohort weaned approximately 1.5 months after enrollment. PTH was 18-30% lower in lactating than in nonlactating women (P < 0.01). Serum 1,25-dihydroxyvitamin D was 11-16% higher in lactating than in nonlactating women and remained elevated for approximately 1.5 months after weaning (P = 0.06). Calcium supplementation decreased serum PTH and 1,25-dihydroxyvitamin D in lactating and nonlactating women similarly. At 6 months, the calciuric response to calcium supplementation was less in lactating (compared with nonlactating) women (P = 0.06). Biomarkers of bone turnover were higher in lactating than in nonlactatingwomen during lactation and after weaning but were not effected by calcium supplementation. Calcium supplementation has little effect on lactation-induced changes in the calcium economy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:26:01