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Titolo:
Immunohistochemical localization of DARPP32 in striatal projection neuronsand striatal interneurons in pigeons
Autore:
Reiner, A; Perera, M; Paullus, R; Medina, L;
Indirizzi:
Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USAUniv Tennessee Memphis TN USA 38163 at & Neurobiol, Memphis, TN 38163 USA Univ Murcia, Fac Med, Dept Morphol Sci, E-30100 Murcia, Spain Univ MurciaMurcia Spain E-30100 Dept Morphol Sci, E-30100 Murcia, Spain
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 1, volume: 16, anno: 1998,
pagine: 17 - 33
SICI:
0891-0618(199812)16:1<17:ILODIS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNERVATED BRAIN-REGIONS; D1 DOPAMINE RECEPTOR; P-LIKE IMMUNOREACTIVITY; NITRIC-OXIDE SYNTHASE; Y-CONTAINING NEURONS; MEDIUM SPINY NEURONS; RAT CAUDATE-PUTAMEN; BASAL GANGLIA; SUBSTANCE-P; GENE-EXPRESSION;
Keywords:
basal ganglia; dopaminoceptive; enkephalin; substance p; cholinergic; neuropeptide Y; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Reiner, A Univs,ennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, 855 Monroe Ave, Memphi Univ Tennessee 855 Monroe Ave Memphis TN USA 38163 e Ave, Memphi
Citazione:
A. Reiner et al., "Immunohistochemical localization of DARPP32 in striatal projection neuronsand striatal interneurons in pigeons", J CHEM NEUR, 16(1), 1998, pp. 17-33

Abstract

DARPP32 is a D1-receptor associated signaling protein found in striatal projection neurons in mammals, including both Substance P-containing (SP+) neurons and enkephalinergic (ENK+) projection neurons. The present study usedimmunohistochemical single- and double-labeling to examine the cellular localization of DARPP32 in pigeon striatum. Single-label studies revealed that DARPP32 is present in numerous medium-sized striatal perikarya and DARPP32+ axons and terminals were seen to profusely innervate the two major striatal projection targets, the pallidum and the substantia nigra. The single-labeling studies indicated that about 60% of all striatal perikarya labeled for DARPP32+ in striatum, which exceeds the abundance of either SP+ or ENKperikarya. Single-labeling studies also showed that the abundance of DARPP32+ fibers and terminals in pallidum exceeds that of either SP+ or ENK+ fibers and terminals in pallidum. Double-labeling found that 30-50% of striatal SP+ perikarya and 7-24% of ENK+ striatal perikarya labeled for DARPP32 inpigeon, and confirmed that DARPP32 was found in both SP+ and ENK+ fibers and terminals in pallidum. In contrast to its prevalence in striatal projection neurons, DARPP32 was virtually absent from cholinergic and NPY+ striatal interneurons, as also true in mammals. Our data are consistent with the interpretation that many SP+ neurons and many ENK+ neurons in avian striatumpossess D1-type dopamine receptors and use a DARPP32 signalling pathway, although this may be more common for SP+ than for ENK+ neurons. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:49:19