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Titolo:
MAP2 expression in developing dendrites of human brainstem auditory neurons
Autore:
Moore, JK; Guan, YL; Shi, SR;
Indirizzi:
House Ear Inst, Dept Neurosurg, Los Angeles, CA 90057 USA House Ear Inst Los Angeles CA USA 90057 rosurg, Los Angeles, CA 90057 USA Univ So Calif, Sch Med, Dept Otolaryngol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 aryngol, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Dept Pathol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Pathol, Los Angeles, CA 90033 USA
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 1, volume: 16, anno: 1998,
pagine: 1 - 15
SICI:
0891-0618(199812)16:1<1:MEIDDO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE-ASSOCIATED PROTEIN-2; SUPERIOR OLIVARY NUCLEUS; AVIAN COCHLEAR NUCLEUS; DIFFERENTIAL SUBCELLULAR-LOCALIZATION; LATERAL GENICULATE-NUCLEUS; N-LAMINARIS; RAT-BRAIN; AFFERENT INFLUENCES; MESSENGER-RNAS; TIME-COURSE;
Keywords:
cytoskeleton; immunohistochemistry; cochlear nuclei; superior olivary complex; inferior colliculus; hearing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, JK House Ear Inst, Dept Neurosurg, 2100 W 3rd St, Los Angeles, CA 90057 USA House Ear Inst 2100 W 3rd St Los Angeles CA USA 90057 90057 USA
Citazione:
J.K. Moore et al., "MAP2 expression in developing dendrites of human brainstem auditory neurons", J CHEM NEUR, 16(1), 1998, pp. 1-15

Abstract

Immunostaining of cytoskeletal elements has proved to be a useful technique for tracing ontogenetic development in the human central auditory system. In the present study, dendritic development in brainstem auditory nuclei (dorsal and ventral cochlear nuclei, medial and lateral superior olivary nuclei, and inferior colliculus) was studied using an antibody to a microtubule-associated protein, MAP2, a molecule which stabilizes dendritic processesby promoting assembly of microtubules. At 21-22 weeks of gestation, cells within the auditory nuclei first demonstrate cytoplasmic MAP2 immunoreactivity, but no dendritic structures have formed. Filamentous background staining at this stage may represent immunoreactivity in astrocytic processes. Bythe 24th fetal week, somata of auditory neurons are strongly immunostainedand have developed short dendritic processes. During the perinatal period,dendrites extend up to 100-120 mu m in length but are still sparsely branched and lack terminal formations. By the sixth postnatal month, neurons in all auditory nuclei have acquired dendritic arbors with a mature appearance. Thus MAP2 immunohistochemistry demonstrates that dendrogenesis in human brainstem auditory nuclei begins 16 weeks prior to term birth but does not reach the stage of mature dendritic morphology until several months into thepostnatal period. This extended course of development implies a significant period of time during which neuronal activity could influence dendritic structure and function. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:48:05