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Titolo:
Increased pulse pressure and risk of heart failure in the elderly
Autore:
Chae, CU; Pfeffer, MA; Glynn, RJ; Mitchell, GF; Taylor, JO; Hennekens, CH;
Indirizzi:
Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA Brigham & Womens Hosp Boston MA USA 02215 event Med, Boston, MA 02215 USA Brigham & Womens Hosp, Div Cardiovasc, Dept Med, Boston, MA 02215 USA Brigham & Womens Hosp Boston MA USA 02215 Dept Med, Boston, MA 02215 USA Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Cardiol, Boston, MA 02114 USA HarvardUSAiv, Sch Med, Dept Ambulatory Care & Prevent, Cambridge, MA 02138Harvard Univ Cambridge MA USA 02138 y Care & Prevent, Cambridge, MA 02138 Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA E Boston Neighborhood Hlth Ctr, E Boston, MA USA E Boston Neighborhood Hlth Ctr E Boston MA USA lth Ctr, E Boston, MA USA
Titolo Testata:
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
fascicolo: 7, volume: 281, anno: 1999,
pagine: 634 - 639
SICI:
0098-7484(19990217)281:7<634:IPPARO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTOLIC BLOOD-PRESSURE; AGE-RELATED-CHANGES; MYOCARDIAL-INFARCTION; ARTERIAL DISTENSIBILITY; NORMOTENSIVE SUBJECTS; AORTIC COMPLIANCE; WAVE VELOCITY; HYPERTENSION; ATHEROSCLEROSIS; PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Chae, CU Brigham02215mens Hosp, Div Prevent Med, 900 Commonwealth Ave E, Boston, MA Brigham & Womens Hosp 900 Commonwealth Ave E Boston MA USA 02215
Citazione:
C.U. Chae et al., "Increased pulse pressure and risk of heart failure in the elderly", J AM MED A, 281(7), 1999, pp. 634-639

Abstract

Context Arterial stiffness increases with age, Thus, pulse pressure, an index of arterial stiffening, may predict congestive heart failure (CHF) in the elderly. Objective To study prospectively the association between pulse pressure and risk of CHF,Design Prospective cohort study. Setting The community-based East Boston Senior Health Project, East Boston, Mass. Patients A total of 1621 men and women (mean [SD] age, 77.9 [5.0] years) free of CHF who had blood pressure measurements taken in 1988-1989 and were followed up for 3.8 years. Main Outcome Measure Incidence of CHF as ascertained by hospital dischargediagnosis (n = 208) and death certificates (n = 13),Results After controlling for age, sex, mean arterial pressure, history ofcoronary heart disease, diabetes mellitus, atrial fibrillation, valvular heart disease, and antihypertensive medication use, pulse pressure was an independent predictor of CHF. For each 10-mm Hg elevation in pulse pressure, there was a 14% increase in risk of CHF (95% confidence interval, 1.05-1.24; P = .003). Those in the highest tertile of pulse pressure (>67 mm Hg) hada 55% increased risk of CHF (P = .02) compared with those in the lowest (<54 mm Hg). Pulse pressure was more predictive than systolic blood pressure alone and was independent of diastolic blood pressure. Conclusion Pulse pressure, an easily measurable correlate of pulsatile hemodynamic load, is an independent predictor of risk of CHF in this elderly cohort.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:36:32