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Titolo:
Exposure of human peripheral blood mononuclear cells (PBMC) to hydrostaticpressure increases their proliferative response to phytohemagglutinin A (PHA) and anti-CD3 antibody
Autore:
Eisenthal, A; Gelfand, A; Misonzhnik, F; Trejo, L; Schwartz, I; Skornick, Y; Lifschitz-Mercer, B;
Indirizzi:
Tel Aviv Sourasky Med Ctr, Inst Pathol, IL-64239 Tel Aviv, Israel Tel AvivSourasky Med Ctr Tel Aviv Israel IL-64239 4239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr, Dept Surg A, IL-64239 Tel Aviv, Israel Tel AvivSourasky Med Ctr Tel Aviv Israel IL-64239 4239 Tel Aviv, Israel
Titolo Testata:
IMMUNOLOGICAL INVESTIGATIONS
fascicolo: 1, volume: 28, anno: 1999,
pagine: 55 - 65
SICI:
0882-0139(1999)28:1<55:EOHPBM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; PROTEIN; IMMUNOTHERAPY; LYMPHOCYTES; COLCHICINE; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenthal, A Tel Aviv Sourasky Med Ctr, Inst Pathol, IL-64239 Tel Aviv, Israel Tel Aviv Sourasky Med Ctr Tel Aviv Israel IL-64239 , Israel
Citazione:
A. Eisenthal et al., "Exposure of human peripheral blood mononuclear cells (PBMC) to hydrostaticpressure increases their proliferative response to phytohemagglutinin A (PHA) and anti-CD3 antibody", IMMUNOL INV, 28(1), 1999, pp. 55-65

Abstract

In the present study we show that a brief exposure of human PBMC to hydrostatic pressure (HyP) increased their proliferative response to PHA and anti-CD3 antibody, assessed by DNA synthesis. The effect of HyP was most prominent at 400 atmospheres of HyP followed by 600 and 200 atmospheres. At any pressure level, the highest effect of HyP was noted when employing PHA and anti-CD3 antibody at 10(-2) dilution. When PBMC were exposed to 400 atmospheres HyP, maximal effect was achieved at 20 minutes of exposure. The highesteffect of HyP on DNA synthesis was noted at 48 and 72 hours of incubation with PHA, when exposing cells to pressure for 20 minutes at 400 atmospheres. Exposure of PBMC under similar conditions for 40 minutes, caused an increase in DNA synthesis only at 48 hours incubation with PHA. These results demonstrate that exposure of human PBMC to HyP increases their proliferative response to different polyclonal activators. The possible mechanisms involved in this phenomenon are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:54:13