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Titolo:
The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc 1638N mouse model
Autore:
van Oordt, CWVH; Smits, R; Schouten, TG; Houwing-Duistermaat, JJ; Williamson, SLH; Luz, A; Khan, PM; van der Eb, A; Breuer, ML; Fodde, R;
Indirizzi:
Leiden Univ, Dept Human Genet, NL-2333 AL Leiden, Netherlands Leiden UnivLeiden Netherlands NL-2333 AL NL-2333 AL Leiden, Netherlands Leiden Univ, Dept Mol Carcinogenesis, NL-2333 AL Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2333 AL NL-2333 AL Leiden, Netherlands Leiden Univ, Dept Med Stat, NL-2333 AL Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2333 AL NL-2333 AL Leiden, Netherlands Univ1Newcastle Upon Tyne, Royal Infirm, Dept Pathol, Newcastle Upon Tyne NE Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE1 7RU GSF, Inst Pathol, Neuherberg, Germany GSF Neuherberg GermanyGSF, Inst Pathol, Neuherberg, Germany
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 3, volume: 24, anno: 1999,
pagine: 191 - 198
SICI:
1045-2257(199903)24:3<191:TGBMTS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL NEOPLASIA; ADENOMATOUS POLYPOSIS; MAJOR MODIFIER; MICE; ACETYLATION; MUTATIONS; LOCUS; CARCINOGENESIS; CANDIDATE; APC1638N;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Fodde, R Leidenlands, Dept Human Genet, Wassenaarseweg 72, NL-2333 AL Leiden, Nether Leiden Univ Wassenaarseweg 72 Leiden Netherlands NL-2333 AL ther
Citazione:
C.W.V.H. van Oordt et al., "The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc 1638N mouse model", GENE CHROM, 24(3), 1999, pp. 191-198

Abstract

The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6J1co-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the Apc(Min) model, the Apc1638N intestinal tumor multiplicity seemsto be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele. Genes Chromosomes Cancer 24: 191-198, 1999. (C) 1999 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:39:08