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Titolo:
Onset and progression of motor deficits in motor neuron degeneration (mnd)mice are unaltered by the glycine/NMDA receptor antagonist L-701,324 or the MAO-B inhibitor R(-)-deprenyl
Autore:
Boyce, S; Webb, JK; Carlson, E; Rupniak, NMJ; Hill, RG; Martin, JE;
Indirizzi:
Mercklandrp & Dohme Res Labs, Ctr Res Neurosci, Harlow CM20 2QR, Essex, Eng Merck Sharp & Dohme Res Labs Harlow Essex England CM20 2QR QR, Essex, Eng Royal London Hosp, Inst Pathol, Dept Morbid Anat, London E1 1BB, England Royal London Hosp London England E1 1BB bid Anat, London E1 1BB, England
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 155, anno: 1999,
pagine: 49 - 58
SICI:
0014-4886(199901)155:1<49:OAPOMD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; WOBBLER MOUSE; NEUROTROPHIC FACTOR; BEHAVIORAL PROFILE; MOTONEURON DISEASE; CONTROLLED TRIAL; MODULATORY SITE; SPINAL-CORD; RILUZOLE; DYSFUNCTION;
Keywords:
neurodegeneration; mnd mouse; glycine NMDA receptor antagonist; R(-)-deprenyl;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Boyce, S Merckrlowrp & Dohme Res Labs, Ctr Res Neurosci, Terlings Pk,Eastwick Rd, Ha Merck Sharp & Dohme Res Labs Terlings Pk,Eastwick Rd Harlow Essex England CM20 2QR
Citazione:
S. Boyce et al., "Onset and progression of motor deficits in motor neuron degeneration (mnd)mice are unaltered by the glycine/NMDA receptor antagonist L-701,324 or the MAO-B inhibitor R(-)-deprenyl", EXP NEUROL, 155(1), 1999, pp. 49-58

Abstract

NMDA-mediated neurotoxicity and oxidative stress have been implicated in the etiology of a number of degenerative diseases including motor neuron disease. The present study examined the effect of chronic administration of the glycine/NMDA receptor antagonist L-701,324 and the monoamine oxidase B inhibitor (R)-deprenyl on the onset and rate of progression of neurological impairment in the motor neuron degeneration (mnd) mouse, a murine model of neurodegeneration. Neurological assessment of mnd mice revealed an onset of motor deficits at 6 months of age as observed by the loss of hindlimb reflex extension, By 7 months, balance was also markedly impaired as measured bydeficits in rotarod performance and ability to remain on balancing beams. At 8 months of age mnd mice exhibited gross abnormalities in walking pattern; animals were unable to flex their hindlimbs and tended to walk in small labored movements, Daily administration of L-701,324 (10 mg/kg p.o.) or R(-)-deprenyl (1 mg/kg p.o.) to mnd mice from 4 to 8 months of age failed to delay the onset of symptoms or slow the rate of deterioration of motor performance. These findings suggest that excessive activation of NMDA receptors may not be involved in the pathological process leading to motor neuron dysfunction in mnd mice and do not suggest a protective effect of deprenyl on motor neurons in these mice. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:15:31