Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
alpha-methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro
Autore:
Drago, F; Marino, A; La Manna, C;
Indirizzi:
Univ Catania, Sch Med, Fac Med, Inst Pharmacol, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 nst Pharmacol, I-95125 Catania, Italy
Titolo Testata:
EXPERIMENTAL EYE RESEARCH
fascicolo: 1, volume: 68, anno: 1999,
pagine: 85 - 90
SICI:
0014-4835(199901)68:1<85:AILMIV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
KOYANAGI-HARADA DISEASE; HUMAN UVEAL MELANOCYTES; INTRAOCULAR-PRESSURE; CHOROIDAL MELANOCYTES; OCULAR HYPERTENSION; MELANOMA-CELLS; HUMAN EYES; GLAUCOMA; TIMOLOL; RADIATION;
Keywords:
melanogenesis; alpha-methyl-p-tyrosine; latanoprost; iris pigmentation; glaucoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Drago, F Univtania,ia, Sch Med, Fac Med, Inst Pharmacol, Viale A Doria 6, I-95125 Ca Univ Catania Viale A Doria 6 Catania Italy I-95125 6, I-95125 Ca
Citazione:
F. Drago et al., "alpha-methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro", EXP EYE RES, 68(1), 1999, pp. 85-90

Abstract

The PGF2 alpha derivative, latanoprost, is a recent anti-glaucoma drug that has been reported to induce a discrete incidence of increased iris pigmentation in men. The present experiments were made in order to study whether this phenomenon could be influenced by the tyrosinase inhibitor, alpha-methyl-p-tyrosine. Melanin content, melanin production and tyrosinase activity of cultured uveal melanocytes derived from irides of brown or brown-blue color were measured after adding latanoprost at different molar concentrationwith or without a-methyl-p-tyrosine (10(-5) M). It was shown that latanoprost stimulated melanin content, melanin production and tyrosinase activity in a molar range between 10(-7) and 10(-5) M in uveal melanocytes derived from irides of both brown and brown-blue color. The effect seemed to be morepronounced in melanocytes derived from irides of brown-blue color. The adding of alpha-methyl-p-tyrosine completely prevented latanoprost-induced stimulation of melanin production in uveal melanocytes derived from irides of both colors. These results suggest that latanoprost-induced stimulation of melanin production, follows the metabolic pathway involving tyrosinase activity and may be relevant for the therapeutic application of latanoprost in glaucoma in order to reduce its side-effect resulting in increased iris pigmentation. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:00:16