Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity
Autore:
Redmond, AM; Harkin, A; Kelly, JP; Leonard, BE;
Indirizzi:
Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland acol, Galway, Ireland
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1-2, volume: 9, anno: 1999,
pagine: 165 - 170
SICI:
0924-977X(199901)9:1-2<165:EOAACA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; MESOLIMBIC DOPAMINE SYSTEM; RAT-BRAIN; NUCLEUS-ACCUMBENS; DIZOCILPINE MK-801; CHANNEL COMPLEX; DRUGS INCREASE; BINDING-SITES; SIGMA; FLUOXETINE;
Keywords:
phencyclidine; fluoxetine; citalopram; paroxetine; sertraline; locomotor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Leonard, BE Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland , Ireland
Citazione:
A.M. Redmond et al., "Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity", EUR NEUROPS, 9(1-2), 1999, pp. 165-170

Abstract

Previously it was found that both acute and chronic antidepressant pre-treatment enhanced the locomotor hyperactivity induced by a challenge injection of the non-competitive NMDA receptor antagonist, dizocilpine (MK-801). Inthe present study the effects of acute and chronic antidepressant administration on phencyclidine (PCP)-induced locomotor hyperactivity were examined. Phencyclidine (PCP), a non-competitive NMDA receptor antagonist increasedlocomotor activity in rats. Fluoxetine given acutely increased and prolonged the PCP-induced locomotor hyperactivity, while citalopram, sertraline and paroxetine had no effect on the PCP-induced behavioural effect. Repeated treatment with fluoxetine, citalopram and paroxetine increased the PCP-induced locomotor hyperactivity. In contrast, chronic sertraline administrationattenuated the locomotor response to a PCP challenge. These results indicate that these antidepressants which are presumed to have a similar pharmacological profile, differ in their ability to alter PCP-induced hyperactivity. Whether these differences have any bearing on the therapeutic or adverse effects of these drugs remains to be shown. (C) 1999 Elsevier Science B.V./ECNP. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:11:18