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Titolo:
CCK4-induced panic in healthy subjects I: psychological and cardiovasculareffects
Autore:
Jerabek, I; Boulenger, JP; Bradwejn, J; Lavallee, YJ; Jolicoeur, FB;
Indirizzi:
Clarke Inst Mental Hlth, Toronto, ON M5T 1R8, Canada Clarke Inst Mental Hlth Toronto ON Canada M5T 1R8 nto, ON M5T 1R8, Canada Univ Sherbrooke, Fac Med, Dept Psychiat, Sherbrooke, PQ J1G 2K8, Canada Univ Sherbrooke Sherbrooke PQ Canada J1G 2K8 erbrooke, PQ J1G 2K8, Canada
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1-2, volume: 9, anno: 1999,
pagine: 149 - 155
SICI:
0924-977X(199901)9:1-2<149:CPIHSI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
YOHIMBINE-INDUCED ANXIETY; CHOLECYSTOKININ-TETRAPEPTIDE; NORADRENERGIC FUNCTION; CARBON-DIOXIDE; HEART-RATE; BEHAVIORAL FINDINGS; LACTATE INFUSIONS; PHOBIC ANXIETY; DISORDER; ATTACKS;
Keywords:
cholecystokinin tetrapeptide; panic; cardiovascular signs; state anxiety; human; healthy subjects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Jerabek, I McGill Univ, Dept Psychiat, 1033 Pine Ave W, Montreal, PQ H3A A1A, Canada McGill Univ 1033 Pine Ave W Montreal PQ Canada H3A A1A , Canada
Citazione:
I. Jerabek et al., "CCK4-induced panic in healthy subjects I: psychological and cardiovasculareffects", EUR NEUROPS, 9(1-2), 1999, pp. 149-155

Abstract

Sixteen healthy subjects participated in a crossover, double blind, and placebo-controlled study, designed to assess simultaneously the psychologicaland cardiovascular effects of cholecystokinin tetrapeptide (CCK4). Following an IV injection of 25 mu g of CCK4, 44 percent of subjects experienced symptoms that fulfilled the DSM-IV criteria for a panic attack while no one panicked with placebo. CCK4 induced a significantly greater number and higher intensity of panic-like symptoms than placebo. A significant increase instate anxiety was observed in the period after CCK4 injection; this increase was significantly larger than the non-specific anxious reaction to placebo. CCK4 also affected cardiovascular signs. Both heart rate and mean bloodpressure significantly increased after administration of CCK4. Again, these increases were significantly higher than those seen after placebo injection. We conclude that, in healthy subjects, CCK4 induces panic-like reactioncharacterized by a number of somatic, cognitive and emotional symptoms, which are accompanied by increases in heart rate and blood pressure. (C) 1999Published by Elsevier Science B.V./ECNP.

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Documento generato il 03/04/20 alle ore 07:54:39