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Titolo:
Plasma monoamine metabolites and aggression: two studies of normal and oppositional defiant disorder children
Autore:
van Goozen, SHM; Matthys, W; Cohen-Kettenis, PT; Westenberg, H; van Engeland, H;
Indirizzi:
UnivtherlandsHosp, Dept Child & Adolescent Psychiat, NL-3508 GA Utrecht, Ne Univ Utrecht Hosp Utrecht Netherlands NL-3508 GA NL-3508 GA Utrecht, Ne Rudolf Magnus Inst Neurosci, NL-3508 TA Utrecht, Netherlands Rudolf MagnusInst Neurosci Utrecht Netherlands NL-3508 TA , Netherlands Univ Utrecht Hosp, Dept Biol Psychiat, Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands ol Psychiat, Utrecht, Netherlands
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1-2, volume: 9, anno: 1999,
pagine: 141 - 147
SICI:
0924-977X(199901)9:1-2<141:PMMAAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; DISRUPTIVE BEHAVIOR DISORDERS; DEFICIT HYPERACTIVITY DISORDER; WHOLE-BLOOD SEROTONIN; H-3 IMIPRAMINE BINDING; CONDUCT DISORDER; 5-HYDROXYINDOLEACETIC ACID; ADOLESCENTS; BOYS; CSF;
Keywords:
serotonin; aggression; child psychiatry; monoamine metabolites;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: van Goozen, SHM UnivUtrecht, Hosp, Dept Child & Adolescent Psychiat, POB 85500, NL-3508 GA Univ Utrecht Hosp POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
S.H.M. van Goozen et al., "Plasma monoamine metabolites and aggression: two studies of normal and oppositional defiant disorder children", EUR NEUROPS, 9(1-2), 1999, pp. 141-147

Abstract

In two studies the relationship between plasma monoamine metabolites and different parameters of aggression were examined in children suffering from severe aggression and antisocial behavior. No prior studies have related measures of serotonergic function to experimentally elicited aggression and only a few included healthy comparison groups. Plasma 5-HIAA, HVA and MHPG were measured in 15 boys with a oppositional defiant disorder (ODD) and 25 normal controls (NC) (study 1), and 22 ODD and 25 NC children (study 2). On a separate occasion each subject had the opportunity to behave aggressivelytowards an opponent. 5-HIAA and HVA were significantly lower in the ODD than NC group and both parameters were significantly inversely correlated with aggression and delinquency. These findings were replicated in the second study. The results of the study support a role for serotonergic functioningin persistent antisocial and aggressive behavior in young children. (C) 1999 Elsevier Science B.V./ECNP. All rights reserved.

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Documento generato il 23/01/20 alle ore 03:43:58