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Titolo:
The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder
Autore:
Plein, H; Berk, M;
Indirizzi:
Univ Witwatersrand, Dept Expt & Clin Pharmacol, Johannesburg, South AfricaUniv Witwatersrand Johannesburg South Africa Johannesburg, South Africa
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1-2, volume: 9, anno: 1999,
pagine: 107 - 110
SICI:
0924-977X(199901)9:1-2<107:TPICRT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC-DISORDERS; DEPRESSED-PATIENTS; MOBILIZATION; NEUROENDOCRINE; ANXIETY;
Keywords:
panic disorder; platelet intracellular calcium response; serotonin; thrombin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Witwatersrand, Dept Psychiat, Johannesburg, South Africa UnivWitwatersrand Johannesburg South Africa burg, South Africa
Citazione:
H. Plein e M. Berk, "The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder", EUR NEUROPS, 9(1-2), 1999, pp. 107-110

Abstract

Serotonin is implicated in both the biology of depression and anxiety. Theaim of this study was to examine the platelet intracellular calcium response to serotonin and thrombin using spectroflouromery in 14 patients with DSM-4 panic disorder compared to 14 matched controls. Patients did not show significantly higher baseline platelet intracellular calcium levels and serotonin stimulated levels of intracellular calcium than control subjects. There was a much smaller standard deviation in the control subjects than in the panic patients. The intracellular calcium response to thrombin activationwas however greater in panic patients than in control subjects (P<0.001). The failure of this study to find enhanced sensitivity of 5-HT2 receptors in panic disorder is compatible with the findings of previous challenge studies that found no consistent dysregulation of serotonin in panic disorder. The enhanced thrombin sensitivity, nevertheless suggests some receptor mediated second messenger changes independent of serotonin in the disorder. (C)1999 Elsevier Science B.V./ECNP. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:32:32