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Titolo:
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test
Autore:
Rezayat, M; Tabarrai, E; Parvini, S; Zarrindast, MR; Pirali, M;
Indirizzi:
Tehran Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran Tehran Univ MedSci Tehran Iran , Sch Med, Dept Pharmacol, Tehran, Iran
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1-2, volume: 9, anno: 1999,
pagine: 9 - 14
SICI:
0924-977X(199901)9:1-2<9:EOCAOG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; RAT-BRAIN; CHOLECYSTOKININ; RECEPTOR; BACLOFEN; MICE; L-364,718; CERULEIN; NEURONS; SYSTEM;
Keywords:
baclofen; THPO; MK-329; L-365,260; proglumide; formalin test; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Rezayat, M Tehran Univ Med Sci, Sch Med, Dept Pharmacol, POB 13145-784, Tehran, Iran Tehran Univ Med Sci POB 13145-784 Tehran Iran 4, Tehran, Iran
Citazione:
M. Rezayat et al., "Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test", EUR NEUROPS, 9(1-2), 1999, pp. 9-14

Abstract

In this work, the influences of CCK receptor antagonists on antinociception induced by the GABA receptor agonist, baclofen, and the GABA uptake inhibitor, THPO, in the formalin test have been studied. GABA-B agonist baclofen(0.75, 1.25 and 2.5 mg/kg), THPO, a GABA uptake inhibitor (1 and 2 mg/kg) and morphine (1.5, 3 and 6 mg/kg) induced antinociception in both phases ofthe formalin test in mice. The selective CCK receptor antagonists, L-365,260, MK-329 (0.05, 0.125 and 0.25 mg/kg) and non-selective CCK receptor antagonist, proglumide (2.5, 5, 10 and 20 mg/kg) induced antinociception only in high doses. The CCK receptor antagonists potentiated baclofen (0.75, 1.25and 2.5 mg/kg) or THPO (1 and 2 mg/kg) responses. It may be concluded thatthe CCK receptor mechanism may interact with GABA-function in its antinociceptive effect. (C) 1999 Elsevier Science B.V./ECNP. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:39:06