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Titolo:
New classes of antihypertensive drugs: Therapeutic potentials
Autore:
Singh, NK; Goyal, RK;
Indirizzi:
Banaras Hindu Univ, Inst Med Sci, Dept Med, Varanasi 221005, Uttar Pradesh, Banaras Hindu Univ Varanasi Uttar Pradesh India 221005 05, Uttar Pradesh, LM Coll Pharm, Ahmedabad, Gujarat, India LM Coll Pharm Ahmedabad Gujarat India l Pharm, Ahmedabad, Gujarat, India
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 1-2, volume: 21, anno: 1999,
pagine: 137 - 143
SICI:
1064-1963(199901/02)21:1-2<137:NCOADT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-CONVERTING ENZYME; ANGIOTENSIN-II; PHARMACOKINETIC PROPERTIES; INTRAVENOUS FENOLDOPAM; HYPERTENSION; INHIBITOR; PHARMACOLOGY; RESPONSES; LOSARTAN;
Keywords:
losartan; fenoldopam; kentaserin; monatepil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, NK Banaras Hindu Univ, Inst Med Sci, Dept Med, Varanasi 221005, Uttar Pradesh, Banaras Hindu Univ Varanasi Uttar Pradesh India 221005 Pradesh,
Citazione:
N.K. Singh e R.K. Goyal, "New classes of antihypertensive drugs: Therapeutic potentials", CLIN EXP HY, 21(1-2), 1999, pp. 137-143

Abstract

A number of new classes of antihypertensive drugs have become available inthe recent years which appear to hold therapeutic potential for better management of hypertension. Losartan, an angiotensin II receptor antagonist, does not produce cough which is classically seen with ACE inhibitors. Fenoldopam, a dopamine D-1-receptor agonist, has a rapid and short duration of action and is ideally suited by intravenous infusion for quick control of BP in hypertensive emergencies. Kentaserin, a serotonin (5-HT2A) receptor antagonist, has a long duration of action and can be given once daily. It has the added benefit of having antiplatelet effect. Monatepil, a dual alpha-receptor and calcium channel blocker, has potent antihypertensive effect, lowers serum cholesterol and also has antiatherosclerotic effect. Dual ACE and endopeptidase inhibitor, such as alatriopril, has a "broad spectrum" antihypertensive effect and may be effective in majority of hypertensive patients. Many other classes of antihypertensive drugs are still in the investigative stage, and their therapeutic potentials and safety need to be ascertained in long-term, controlled clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:19:38