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Titolo:
Evaluation of a new self-expandable silicone stent in an experimental tracheal stenosis
Autore:
Bolliger, CT; Wyser, C; Wu, XR; Hauser, R; Studer, W; Dalquen, P; Perruchoud, AP;
Indirizzi:
Univ Basel Hosp, Div Resp, Dept Internal Med, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ed, CH-4031 Basel, Switzerland Univ Basel Hosp, Div Resp, Dept Anesthesiol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Univ Basel Hosp, Div Resp, Dept ENT, CH-4031 Basel, Switzerland Univ BaselHosp Basel Switzerland CH-4031 NT, CH-4031 Basel, Switzerland Univ Basel Hosp, Div Resp, Dept Pathol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland
Titolo Testata:
CHEST
fascicolo: 2, volume: 115, anno: 1999,
pagine: 496 - 501
SICI:
0012-3692(199902)115:2<496:EOANSS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACHEOBRONCHIAL STENOSES; AIRWAY WALLSTENT; MULTICENTER; MANAGEMENT; PROGRESS; WORK;
Keywords:
animal model; central airway obstruction; stents; tracheal stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Bolliger, CT Univ,Basel Hosp, Div Resp, Dept Internal Med, Petersgraben 4,CH-4031 Basel Univ Basel Hosp Petersgraben 4 Basel Switzerland CH-4031 sel
Citazione:
C.T. Bolliger et al., "Evaluation of a new self-expandable silicone stent in an experimental tracheal stenosis", CHEST, 115(2), 1999, pp. 496-501

Abstract

Study objectives: To assess the usefulness of an animal model for testing new tracheobronchial stents. Setting: Animal laboratory of a university hospital. Animals and interventions: In a series with 12 mini-pigs, we induced a stable fibromalacic tracheal stenosis that was 50% to 70% of the normal tracheal diameter. After dilation we inserted a 16 x 40-mm self-expandable silicone stent into the stenotic part of the trachea in 10 of the mini-pigs. Fiveof the stents had a smooth outer surface, and five had additional siliconeretaining spikes. Because of a long stenosis in two of the mini-pigs, two overlapping stents tone smooth and one with spikes) were inserted. Measurements and results: Stent deployment was successful and resulted in the disappearance of the slight to moderate strider in all of the mini-pigs. Over a mean (+/- SD) observation period of 24 days (range, 10 to 41 days), all of the mini-pigs redeveloped strider. Three of them died unexpectedlyof suffocation: in all three a smooth stent had mi,orated, leading to total obstruction of the stenosis. In total, five of the six smooth stents migrated, and only one of the six spiked stents migrated. There was considerable granulation tissue formation at the ends of all of the stents. In the twocontrol mini-pigs, a 12 x 35-mm Dumon stent was inserted. Both Dumon stents migrated, and one of them had considerable granuloma formation at its ends. At the end of the observation period, all stents were removed endoscopically and were found not to have deteriorated over time,Conclusions: Our model proved to be suitable for the evaluation of the technical aspects of the Polyflex stent, Spikes on the outer stent surface aremore effective in preventing migration than smooth-surface stents. Long-term compatibility, however, seems to be difficult to test with our model because both the Bob-flex and the Dumon stents had excessive granulation tissue formation at both ends, a factor which-in the case of the Dumon stent-does not occur to such a degree in benign human airway stenoses. Our results indicate a need for prospective long-term studies in benign human airway stenoses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:00:45