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Titolo:
Contribution of cholinergic and gabaergic functions to memory processes inBALB/cANnCrlBR mice
Autore:
Messier, C; Wall, PM; Ethier, K;
Indirizzi:
Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Psychol, Ottawa, ON K1N 6N5, Canada
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 818, anno: 1999,
pagine: 583 - 592
SICI:
0006-8993(19990213)818:2<583:COCAGF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DIABETIC RATS; FREELY MOVING RATS; ACETYLCHOLINE-RELEASE; AGED RATS; CEREBRAL GLUCOSE; IN-VIVO; BRAIN; SCOPOLAMINE; ANTAGONISTS; MECHANISMS;
Keywords:
hippocampus; memory; diabetes; glucose; insulin; muscimol; oxotremorine; bicuculline; acetylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Messier, C Univ Ottawa, Sch Psychol, Vanier Room 215, Ottawa, ON K1N 6N5, Canada Univ Ottawa Vanier Room 215 Ottawa ON Canada K1N 6N5 N5, Canada
Citazione:
C. Messier et al., "Contribution of cholinergic and gabaergic functions to memory processes inBALB/cANnCrlBR mice", BRAIN RES, 818(2), 1999, pp. 583-592

Abstract

Several lines of evidence indicate that glucose influences on memory depend on interactions between glucose, glucoregulation and hippocampal cholinergic function. We previously demonstrated that glucose and scopolamine differentially affected memory consolidation for an operant bar pressing task intwo closely-related BALB/c mouse strains. Whereas glucose normally improves memory in several animal strains, memory consolidation was not effected by systemic glucose injections in BALB/cANnCrlBR mice. Moreover, these mice were relatively insensitive to the normally observed amnestic effects of scopolamine. We therefore sought to determine whether cholinergic mechanisms in the dorsal hippocampus were involved in such atypical drug effects on memory processing in that strain of mice. In Experiment 1, we examined whether post-training oxotremorine would also atypically influence memory consolidation for an appetitively reinforced operant bar pressing task following microinjection in the dorsal hippocampus. In Experiment 2, we examined the effects of intrahippocampal GABA(A) drugs on memory consolidation. The non-selective muscarinic agonist, oxotremorine, dose-dependently impaired memoryand the GABA(A) antagonist, bicuculline, improved retention in BALB/cANnCrlBR mice. It was concluded that GABA-mediated influences on hippocampal pyramidal output in BALB/cANnCrlBR mice and other strains are similar; but theamnestic effects of oxotremorine from the dorsal hippocampus were oppositeto facilitating effects normally observed in other animal strains. Resultsare discussed relative to possible altered septo-hippocampal cholinergic neurotransmission in BALB/cANnCrlBR mice. (C) 1999 Elsevier Science B.V. Allrights reserved.

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Documento generato il 25/11/20 alle ore 15:14:19