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Titolo:
HYPOCHOLESTEROLEMIC ACTIONS OF ATORVASTATIN ARE ASSOCIATED WITH ALTERATIONS ON HEPATIC CHOLESTEROL-METABOLISM AND LIPOPROTEIN COMPOSITION IN THE GUINEA-PIG
Autore:
CONDE K; VERGARAJIMENEZ M; KRAUSE BR; NEWTON RS; FERNANDEZ ML;
Indirizzi:
UNIV ARIZONA,LIPID METAB LAB TUCSON AZ 85721 UNIV ARIZONA,DEPT NUTR SCI TUCSON AZ 85721 UNIV ARIZONA,INTERDISCIPLINARY NUTR SCI PROGRAM TUCSON AZ 85721 WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES ANN ARBOR MI 48105
Titolo Testata:
Journal of lipid research
fascicolo: 11, volume: 37, anno: 1996,
pagine: 2372 - 2382
SICI:
0022-2275(1996)37:11<2372:HAOAAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; COA REDUCTASE INHIBITORS; COENZYME-A REDUCTASE; ENZYMATIC DETERMINATION; FED RABBIT; ACYL-COA; PLASMA; LOVASTATIN; TRIGLYCERIDE; SIMVASTATIN;
Keywords:
ATORVASTATIN; LDL; ACAT; HMG-COA REDUCTASE INHIBITORS; APO-B SECRETION RATES; GUINEA PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
K. Conde et al., "HYPOCHOLESTEROLEMIC ACTIONS OF ATORVASTATIN ARE ASSOCIATED WITH ALTERATIONS ON HEPATIC CHOLESTEROL-METABOLISM AND LIPOPROTEIN COMPOSITION IN THE GUINEA-PIG", Journal of lipid research, 37(11), 1996, pp. 2372-2382

Abstract

Guinea pigs were fed 15% (w/w) fat, high in lauric and myristic acids, a diet known to produce hypercholesterolemia in these animals. The diet was given alone or in combination with four doses of atorvastatin equivalent to 1, 3, 10, and 20 mg/kg per day. Atorvastatin reduced plasma LDL cholesterol concentrations by 46, 50, 53, and 70%, respectively (P < 0.001). Plasma apoB concentrations were reduced by atorvastatin(P < 0.001) and compositional changes occurred in VLDL and LDL with reductions of the relative proportion of cholesteryl ester and increases in triacylglycerol. A reduction in hepatic cholesteryl ester (66%) was observed only with the highest atorvastatin dose (20 mg/kg per day)while microsomal cholesterol was reduced by 30% with 3-20 mg/kg per day. Hepatic ACAT activity was down-regulated and apoB/E receptor number was increased by atorvastatin. In contrast, HMG-CoA reductase activity and cholesterol 7 alpha-hydroxylase were not affected by the drug. VLDL apoB secretion rates were decreased by atorvastatin treatment 59 and 76% with 3 and 20 mg/kg per day, respectively. Nascent VLDL particles were larger after drug treatment, showing an increased number in triacylglycerol molecules. These results support the hypothesis that the plasma LDL lowering induced by atorvastatin is due to a decreased secretion of apoB in combination with an increase of hepatic apoB/E receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:18:08