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Titolo:
Decreased platelet alpha-2 adrenoceptor density in major depression: Effects of tricyclic antidepressants and fluoxetine
Autore:
Maes, M; Van Gastel, A; Delmeire, L; Meltzer, HY;
Indirizzi:
Univ60ntwerp, Dept Psychiat, AZ Stuivenberg, Clin Res Ctr Mental Hlth, B-20 Univ Antwerp Antwerp Belgium B-2060 berg, Clin Res Ctr Mental Hlth, B-20 Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 45, anno: 1999,
pagine: 278 - 284
SICI:
0006-3223(19990201)45:3<278:DPAADI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL-AXIS; ALPHA-2-ADRENERGIC RECEPTORS; PLASMA NOREPINEPHRINE; AFFECTIVE-DISORDER; ALPHA(2)-ADRENERGIC RECEPTORS; H-3-IMIPRAMINE BINDING; SYMPATHOADRENAL SYSTEM; CEREBROSPINAL-FLUID; FUNCTIONAL EVIDENCE; BETA-ADRENOCEPTORS;
Keywords:
catecholamines; rauwolscine; fluoxetine; depression; alpha-2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Maes, M UnivLangeerp, Dept Psychiat, AZ Stuivenberg, Clin Res Ctr Mental Hlth, 267 Univ Antwerp 267 Lange Beeldekensstr Antwerp Belgium B-2060 , 267
Citazione:
M. Maes et al., "Decreased platelet alpha-2 adrenoceptor density in major depression: Effects of tricyclic antidepressants and fluoxetine", BIOL PSYCHI, 45(3), 1999, pp. 278-284

Abstract

Background: It has been suggested that major depression is accompanied by a subsensitivity of central alpha 2-adrenoceptors (alpha 2-ARs) and, consequently, by an impaired negative feedback on the presynaptic catecholaminergic neuron, which, in turn, may induce a disinhibition of noradrenergic output and norepinephrine release in response to any activation. Methods: The maximum number of platelet binding sites (Bmax) and their affinity for [H-3]-rauwolscine, a selective alpha 2-AR antagonist, were measured in unmedicated and medicated major depressed patients and in normal volunteers. Specific binding was defined as that inhibited by idazoxan, anotheralpha 2-AR antagonist. Results: Unmedicated major depressed patients had significantly decreased platelet [H-3]-rauwolscine binding Bmax values compared to normal volunteers. [H-3]-rauwolscine binding K-d values did not differ significantly between unmedicated major depressed patients and normal controls. [H-3]-rauwolscine binding Bmax or K-d values. [H-3]-rauwolscine binding Bmax values were significantly greater in men than in women. Conclusions: The results suggest that i) major depression is accompanied by decreased platelet alpha 2-AR density; and the ii) subchronic treatment with tricyclic antidepressants, but not fluoxetine, results in a decreased affinity of rauwolscine for platelet alpha 2-ARs. Biol Psychiatry 1999; 45:278-284 (C) 1999 Society of Biological Psychiatry.

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Documento generato il 22/01/20 alle ore 21:48:45