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Titolo:
Immunolocalization of high-density lipoproteins in arterial walls of rats
Autore:
Yang, VC; Lee, TY; Hwang, GY; Kao, CH; Chen, JK;
Indirizzi:
Tunghai Univ, Dept Biol, Taichung 40704, Taiwan Tunghai Univ Taichung Taiwan 40704 iv, Dept Biol, Taichung 40704, Taiwan Chang Gung Coll Med & Technol, Dept Physiol, Lin Kou, Taiwan Chang Gung Coll Med & Technol Lin Kou Taiwan t Physiol, Lin Kou, Taiwan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 142, anno: 1999,
pagine: 269 - 277
SICI:
0021-9150(199902)142:2<269:IOHLIA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE CHOLESTEROL TRANSPORT; A-I; ENDOTHELIAL-CELLS; BRANCHED REGIONS; HDL CHOLESTEROL; LOW-TEMPERATURE; APOA-I; PLASMA; RECEPTOR; EFFLUX;
Keywords:
immunolocalization; high-density lipoprotein; arterial wall; high-cholesterol diet; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, VC Tunghai Univ, Dept Biol, Taichung 40704, Taiwan Tunghai Univ Taichung Taiwan 40704 Biol, Taichung 40704, Taiwan
Citazione:
V.C. Yang et al., "Immunolocalization of high-density lipoproteins in arterial walls of rats", ATHEROSCLER, 142(2), 1999, pp. 269-277

Abstract

The inverse correlation between serum high-density lipoprotein (HDL) levels and coronary heart disease in humans suggests that HDL has a protective effect against the development of atherosclerosis. However, then is a lack of data concerning its distribution across the arterial wall. In order to detect this lipoprotein, we performed immunogold labeling on ultrathin sections of L.R. White embedded rat arterial tissue. Electron microscopic examination revealed that HDL was localized in the cytoplasm of the endothelial cells and the smooth muscle cells, but not in the nucleus or other organelles. The HDL was also present in the subendothelial space, the extracellular matrix as well as the intercellular clefts between the endothelial cells. Quantitative study revealed that rats on a high cholesterol diet for one month have more immunogold labeling (P < 0.05) in the subendothelial space, thesmooth muscle cells and the extracellular matrix as compared to rats on a normal diet. After 12 months of normal diet, the intracellular labeling wassignificantly increased (P < 0.05) in the endothelial cells and the smoothmuscle cells as compared to 1 month on the normal diet. The increase was greater (P < 0.05) for the high-cholesterol diet than for the normal dirt treatment. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:55:19