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Titolo:
Biopsychological and cognitive differences in children with premature vs on-time adrenarche
Autore:
Dorn, LD; Hitt, SF; Rotenstein, D;
Indirizzi:
Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Nursing, Pittsburgh, PA 15261 USA Alleghenyittsburgh, Med Coll Penn & Hahnemann Univ, Sch Med, Dept Pediat, P Allegheny Gen Hosp Pittsburgh PA USA 15212 Univ, Sch Med, Dept Pediat, P
Titolo Testata:
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
fascicolo: 2, volume: 153, anno: 1999,
pagine: 137 - 146
SICI:
1072-4710(199902)153:2<137:BACDIC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE SPOTTED HYENAS; PRECOCIOUS PUBERTY; YOUNG ADOLESCENTS; MAJOR DEPRESSION; BIOLOGICAL MATURATION; POSTMENOPAUSAL WOMEN; ACANTHOSIS NIGRICANS; ANXIETY DISORDERS; SEXUAL-BEHAVIOR; NEGATIVE AFFECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Dorn, LD Univh,ittsburgh, Sch Nursing, 3500 Victoria St,440 Victoria Bldg,Pittsburg Univ Pittsburgh 3500 Victoria St,440 Victoria Bldg Pittsburgh PAUSA 15261
Citazione:
L.D. Dorn et al., "Biopsychological and cognitive differences in children with premature vs on-time adrenarche", ARCH PED AD, 153(2), 1999, pp. 137-146

Abstract

Background: Puberty consists of 2 components: gonadarche and adrenarche. Both components have distinct endocrine changes. Adrenarche has virtually been ignored with respect to examining hormone-behavior relations. Objectives: To provide descriptive biological and behavioral information on children with premature adrenarche (PA) and to examine differences in biological, psychological, and cognitive variables of children with PA and a healthy comparison group of children with on-time adrenarche. Design: Descriptive pilot study. Setting: A consecutive sample of patients was recruited from pediatric endocrine clinics; comparison children were recruited from the community. Participants: Children aged 6 to 9 years. Mean (+/-SD) age of children with PA (n = 9) was 7.8 (+/-1.3) years; of children with on-time adrenarche (n= 20), 8.0 (+/-1.2) years. Methods and Measures: Serum and saliva samples were collected for measurement of hormone concentrations. Questionnaires, tests, and interviews were completed by children and parents. Results: Compared with the on-time group, the PA group had significantly higher concentrations of adrenal androgens, estradiol, thyrotropin, and cortisol. By parent report on the Diagnostic Interview Schedule for Children, 4children (44%) met diagnostic criteria for psychological disorders (primarily anxiety disorders). The PA group also had more self-reported depressionand parent-reported behavior problems and lower scores on various intelligence tests. Conclusions: Although PA is considered a normal variation of pubertal development that warrants no medical intervention, PA presents with significantpsychosocial problems. Children with PX may need psychological evaluation and follow-up. Future studies should confirm these findings with a larger sample and examine the long-term ramifications of this early presenting abnormality.

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Documento generato il 20/01/21 alle ore 10:56:56