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Titolo:
Agreement in pathologic interpretation of liver biopsy specimens in posttransplant hepatitis C infection
Autore:
Younossi, ZM; Boparai, N; Gramlich, T; Goldblum, J; George, P; Mayes, J;
Indirizzi:
Cleveland Clin Fdn, Dept Gastroenterol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 nterol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Biostat, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 iostat, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Liver Transplant Ctr, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 nt Ctr, Cleveland, OH 44195 USA
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 2, volume: 123, anno: 1999,
pagine: 143 - 145
SICI:
0003-9985(199902)123:2<143:AIPIOL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANTATION; REJECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Younossi, ZM Clevelandd,lin Fdn, Dept Gastroenterol, Desk S-40,9500 EuclidAve, Clevelan Cleveland Clin Fdn Desk S-40,9500 Euclid Ave Cleveland OH USA 44195
Citazione:
Z.M. Younossi et al., "Agreement in pathologic interpretation of liver biopsy specimens in posttransplant hepatitis C infection", ARCH PATH L, 123(2), 1999, pp. 143-145

Abstract

Hepatitis C virus-related disease is rapidly becoming the most common indication for orthotopic liver transplant (OLT) in the United States. Althoughpost-OLT hepatitis C viremia is universal, 40% to 60% of patients develop recurrent chronic hepatitis C. Distinguishing recurrent chronic hepatitis Cinfection from acute rejection may be difficult because of overlapping histopathologic features. To improve our diagnostic accuracy we undertook a study to determine interobserver and intraobserver agreement between pathologists examining post-OLT liver biopsy specimens in patients from our transplant database. Clinical data and microscopic sections from 26 patients with hepatitis C virus-related OLT were reviewed. Biopsy specimens were obtainedbecause of abnormal liver enzymes (21/26) or routine post-OLT follow-up (5/26), representing both early (18 +/- 11 days) and late (252 +/- 206 days) post-OLT periods. Unidentified sections were examined by an experienced pathologist in a randomly assigned order and reexamined 6 weeks later in the same fashion by the initial reviewer and a second experienced pathologist. Interobserver and intraobserver agreement was calculated using kappa statistic. The intraobserver agreement was 81% with a kappa coefficient of 0.67 (P= .001). The interobserver agreement was 78% with a kappa coefficient of 0.60 (P < .001). The early post-OLT biopsy specimens (18 +/- 11 days) were the most difficult to interpret.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 03:35:53