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Titolo:
Heritability estimates for psychotic disorders - The Maudsley Twin psychosis series
Autore:
Cardno, AG; Marshall, EJ; Coid, B; Macdonald, AM; Ribchester, TR; Davies, NJ; Venturi, P; Jones, LA; Lewis, SW; Sham, PC; Gottesman, II; Farmer, AE; McGuffin, P; Reveley, AM; Murray, RM;
Indirizzi:
Univ Wales, Coll Med, Dept Psychol Med, Cardiff CF4 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF4 4XN d, Cardiff CF4 4XN, S Glam, Wales Inst Psychiat, London, England Inst Psychiat London EnglandInst Psychiat, London, England Univ La Sapienza, Dept Psychiat Sci & Psychol Med, Rome, Italy Univ La Sapienza Rome Italy ept Psychiat Sci & Psychol Med, Rome, Italy Withington Hosp, Dept Psychiat, Manchester M20 8LR, Lancs, England Withington Hosp Manchester Lancs England M20 8LR M20 8LR, Lancs, England Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 2, volume: 56, anno: 1999,
pagine: 162 - 168
SICI:
0003-990X(199902)56:2<162:HEFPD->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPERATIONALLY DEFINED SCHIZOPHRENIA; POPULATION-ASCERTAINED SUBSAMPLES; PILOT SWEDISH TWIN; AFFECTIVE-ILLNESS; CONCORDANCE; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Cardno, AG UnivWaless, Coll Med, Dept Psychol Med, Heath Pk, Cardiff CF4 4XN, S Glam, Univ Wales Heath Pk Cardiff S Glam Wales CF4 4XN 4 4XN, S Glam,
Citazione:
A.G. Cardno et al., "Heritability estimates for psychotic disorders - The Maudsley Twin psychosis series", ARCH G PSYC, 56(2), 1999, pp. 162-168

Abstract

Background: Previous twin studies have supported a genetic contribution tothe major categories of psychotic disorders, but few of these have employed operational diagnostic criteria, and no such study has been based on a sample that included the full range of functional psychotic disorders. Methods: A total of 224 twin probands (106 monozygotic, 118 dizygotic) with a same-sex co-twin and a lifetime history of psychosis was ascertained from the service-based Maudsley Twin Register in London, England. Research Diagnostic Criteria psychotic diagnoses were made on a lifetime-ever basis. Main-lifetime diagnoses of DSM-III-R and International Statistical Classification of Diseases, 10th Revision schizophrenia were also made. Pro-bandwiseconcordance rates and correlations in liability were calculated, and biometrical model fitting applied. Results: A substantial genetic contribution to variance in liability was confirmed for the major diagnostic categories except Research Diagnostic Criteria depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed, but the relative contribution of genetic and common environmental factors was unclear. Heritability estimates for Research Diagnostic Criteria schizophrenia, schizoaffective disorder, mania, DSM-III-R schizophrenia, and International Statistical Classification of Diseases, 10th Revision schizophrenia were all between 82% and 85%. None of the estimates differed significantly from any other. Conclusions: Heritability estimates for schizophrenia, schizoaffective disorder, and mania were substantial and similar. Population morbid risk estimates were inferred rather than directly measured, but the results were verysimilar to those from studies where morbid risks were directly estimated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:47:07